A3940

1-Aminobenzotriazole

≥98% (TLC), powder, cytochrome P450 inhibitor

• Synonym(s): 1-Benzotriazolamine, ABT
• Linear Formula: H₂NC₆H₄N₃
• CAS Number: 1614-12-6
• Molecular Weight: 134.14
• NACRES: NA.77
• PubChem Substance ID: 24278226
• UNSPSC Code: 12352200
• MDL number: MFCD00132902
• Beilstein/REAXYS Number: 607843
• Assay: ≥98% (TLC)
• Form: powder

Properties

• Product Name: 1-Aminobenzotriazole,
• assay: ≥98% (TLC)
• Quality Segment: 200
• form: powder
• greener alternative product score: old score: 93; new score: 46; Find out more about DOZN™ Scoring
• greener alternative product characteristics: Waste Prevention; Safer Solvents and Auxiliaries; Inherently Safer Chemistry for Accident Prevention; Learn more about the Principles of Green Chemistry.
• sustainability: Sustainability features, Sustainability features
• mp: 81-84 °C (lit.)
• solubility: ethanol: 49-51 mg/mL, clear, pale yellow to yellow
• SMILES string: Nn1nnc2ccccc12
• InChI: 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
• InChI key: JCXKHYLLVKZPKE-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Description

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Application

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves