A6060

Calpain Inhibitor II

powder

• Synonym(s): N-Acetyl-L-leucyl-L-leucyl-L-methioninal
• Empirical Formula (Hill Notation): C₁₉H₃₅N₃O₄S
• CAS Number: 110115-07-6
• Molecular Weight: 401.56
• UNSPSC Code: 12352200
• NACRES: NA.77
• PubChem Substance ID: 24891051
• MDL number: MFCD00065506
• Beilstein/REAXYS Number: 7693643
• eCl@ss: 32110502
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• assay: ≥95% (HPLC)
• Quality Segment: 100
• form: powder
• color: white
• solubility: ethanol: 20 mg/mL
• storage temp.: −20°C
• SMILES string: [H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O
• InChI: 1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
• InChI key: RJWLAIMXRBDUMH-ULQDDVLXSA-N

Description

Application

Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Calpain Inhibitor II has been used in western blotting. It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.

Biochem/physiol Actions

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.

Other Notes

Formerly CAS# 136632-32-1

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)