C0913
Complement C2 deficient serum human
for complement assays
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| Size/SKU | Availability | Price |
|---|---|---|
1 mL | Please contact Customer Service for Availability | 7 780,00 CZK |
About This Item
Form:
liquid
Biological source:
human
7 780,00 CZK
Save Up To 15%
Please contact Customer Service for Availability
Application
C2 is a critical protease for compliment activation, which supports bacterial killing via phagocytes. C2 can be used in research to explore the mechanisms by which bacterial pathogens evade detection by the compliment system. One such mechanism by the bacteria Pseudomonas aeruginosa, uses the alkaline protease (AprA) to degrade and cleave C2 which ultimately interferes with the classical and lectin pathways. Research has shown that C2 deficiency results in an increased risk of infection by Streptococcus pyogenes through impaired phaogocytosis and neutrophil dependent killing.
Biochem/physiol Actions
Physical form
Supplied as a solution in PBS, pH 7.2
Analysis Note
C2 is depleted by immunoadsorption method as judged by a highly sensitive hemolytic assay and Ouchterlony immunodiffusion method.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
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This Item | |||
|---|---|---|---|
| description for complement assays | description for complement assays | description for complement assays | description ≥150,000 C9H50 units/mg (using C9 deficient serum) |
| biological source human | biological source human | biological source human | biological source human |
| technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) activity assay: suitable | technique(s) - |
| form liquid | form liquid | form solution | form solution |
| storage temp. −70°C | storage temp. −70°C | storage temp. −70°C | storage temp. −70°C |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| Gene Information human ... C2(717) | Gene Information human ... C6(729) | Gene Information human ... C5(727) | Gene Information human ... C9(735) |
Storage Class
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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