Key Documents

View All Documentation

8-Cyclopentyl-1,3-dipropylxanthine

Name: 8-Cyclopentyl-1,3-dipropylxanthine
Brand: SIGMA
Price: 2280 CZK

A1 adenosine receptor antagonist, solid

Synonym(s):

1,3-Dipropyl-8-cyclopentylxanthine, DPCPX, PD 116,948

Select a Size

Change View

Size/SKU	Availability	Price
25 mg	Please contact Customer Service for Availability	2 280,00 CZK
100 mg	Please contact Customer Service for Availability	4 970,00 CZK 4 224,50 CZK

About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₄N₄O₂

CAS Number:

102146-07-6

Molecular Weight:

304.39

UNSPSC Code:

12352202

PubChem Substance ID:

24277697

NACRES:

NA.77

MDL number:

MFCD00055117

Form:

solid

2 280,00 CZK

Please contact Customer Service for Availability

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

8-Cyclopentyl-1,3-dipropylxanthine, solid

form

solid

Quality Segment

100

color

white

solubility

DMSO: >10 mg/mL, 0.1 M NaOH: 2 mg/mL, ethanol: 4 mg/mL, H₂O: insoluble

ε_max

14,800 at 276 nm in ethanol

SMILES string

CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)C3CCCC3

InChI

1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)

InChI key

FFBDFADSZUINTG-UHFFFAOYSA-N

Gene Information

human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)

Description

Application

8-Cyclopentyl-1,3-dipropylxanthine has been used as an adenosine receptor (A1AR) antagonist in macrophages and human umbilical vein endothelial cells (HUVECs). It has also been used as A1AR antagonist in MCF-7 breast cancer cell line to test its anti-cancer effect.

Biochem/physiol Actions

8-Cyclopentyl-1,3-dipropylxanthine (DPCPX) is a selective A1 adenosine receptor antagonist. DPCPX possesses anti-cancer functionality. It induces apoptosis in breast cancer cells and favors mRNA expression of caspases.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	119147	C102	410957
Sigma-Aldrich C101 8-Cyclopentyl-1,3-dipropylxanthine	Sigma-Aldrich 119147 Adenosine A1 Receptor Antagonist I	Sigma-Aldrich C102 8-Cyclopentyl-1,3-dimethylxanthine	Sigma-Aldrich 410957 3-Isobutyl-1-methylxanthine
description solid	description DPCPX	description ≥98% (HPLC), powder	description A cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC₅₀= 2-50 µM).
form solid	form white solid	form powder	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility 0.1 M NaOH: 2 mg/mL, DMSO: >10 mg/mL, ethanol: 4 mg/mL, H₂O: insoluble	solubility soluble (DMSO (5 mM))	solubility DMSO: ~16 mg/mL at 60 °C, 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.77 mg/mL, H₂O: slightly soluble <0.28 mg/mL, 0.1 M NaOH: soluble	solubility ethanol: 10 mg/mL, methanol: 50 mg/mL, DMSO: 100 mM
color white	color -	color white to off-white	color white
Gene Information human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140) rat ... Adora1(29290), Adora2a(25369), Adora2b(29316), Adora3(25370)	Gene Information -	Gene Information human ... ADORA1(134)	Gene Information -
ε_max 14,800 at 276 nm in ethanol	ε_max -	ε_max -	ε_max -

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Anonymous

a year ago

Qual a temperatura de armazenamento do C101?

1 answer
1. Technical Support
  
  a year ago
  
  This product may be stored at room temperature.
  
  Helpful?

Reviews

No rating value