C1603

Anti-Calcium Channel (α_1C Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CACH2, Anti-CACN2, Anti-CACNL1A1, Anti-CCHL1A1, Anti-CaV1.2, Anti-LQT8, Anti-TS, Anti-TS. LQT8
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD02095952
• eCl@ss: 32160702
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 14

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human, rat, mouse, rabbit
• technique(s): immunohistochemistry: suitable using Rat brain sections, western blot: 1:200 using Rat brain and rat heart membranes
• UniProt accession no.: Q13936
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: mouse ... Cacna1c(12288)

Description

General description

L-type of Voltage-gated Ca2+ Channels (L-type VGCC) is a high voltage-activated channel that exerts spatial and temporal control over cellular calcium concentrations and modulates function such as neurotransmitter release, hormone secretion, muscle contraction, electrical activity, cell metabolism and proliferation, gene expression and neuronal survival. Calcium dependent processes are important in synaptic modification and thus alterations in calcium channel function may be important for both modifying synaptic plasticity and also in age-related neurodegenerative diseases. Calcium channel antagonists are used as antiarrhythmics and in the treatment of hypertension and may even be neuroprotective in Parkinson′s Disease. Calcium Channel α1C subunit is a pore-forming subunit that together with β subunits generates the necessary signal for membrane targeting of class C L-type calcium channels.

Immunogen

synthetic peptide corresponding to amino acids 848 to 865 of rat α_1C.

Application

Anti-Calcium Channel (α_1C Subunit) (L-type of Voltage-gated Ca²⁺ Channel) antibody produced in rabbit has been used in:

• SDS-PAGE
• western blotting
• coimmunoprecipitation

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Rabbit polyclonal anti-Calcium Channel α1C subunit antibody is used to tag class C L-type calcium channel subunit α1C for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques such as ELISA, immunoblotting, and immunoprecipitation. It is used as a probe to determine the presence and roles of calcium channel subunit α1C in class C L-type voltage-gated Ca²⁺ channel subunit complexes.

Biochem/physiol Actions

Anti-Voltage-gated Calcium Channel α1C subunit recognizes the α1C subunit by immunoblotting in rat brain and rat heart membranes. Reactivity has been confirmed for rat, mouse, rabbit and human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable