This product has not been tested for in vivo use. The material is soluble at 50 mg/mL in 1N HCl. The stock solution would require sterile filtration before further dilution with a sterile buffer or medium.
C6506
4-Chloro-DL-phenylalanine
5-HT synthesis inhibitor, solid
Sustainability features
Synonym(s):
PCP, PCPA
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| Size/SKU | Availability | Price |
|---|---|---|
5 g | Please contact Customer Service for Availability | 2 840,00 CZK |
25 g | Please contact Customer Service for Availability | 9 720,00 CZK |
About This Item
Linear Formula:
ClC6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
199.63
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
231-051-9
MDL number:
Product Name
4-Chloro-DL-phenylalanine,
form
solid
Quality Segment
greener alternative product score
old score: 2
new score: 1
Find out more about DOZN™ Scoring
sustainability
Sustainability features
mp
>240 °C (dec.) (lit.)
storage temp.
room temp
SMILES string
NC(Cc1ccc(Cl)cc1)C(O)=O
InChI
1S/C9H10ClNO2/c10-7-3-1-6(2-4-7)5-8(11)9(12)13/h1-4,8H,5,11H2,(H,12,13)
InChI key
NIGWMJHCCYYCSF-UHFFFAOYSA-N
Gene Information
human ... TPH1(7166), TPH2(121278)
General description
We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles "Less Hazardous Chemical Syntheses", "Designing Safer Chemicals" and "Design for Energy Efficiency". Click here to view its DOZN scorecard.
Application
4-Chloro-DL-phenylalanine has been used:
- as tryptophan hydroxylase 1 (TPH1) inhibitor to treat kras+ male zebrafish
- to induce insomnia in rat models
- used to treat embryos to examine its effect on serotonin
- for the selection of Enterococcus faecalis transformants with pESentA32 plasmid
- to feed flies to explore serotonin effect
Biochem/physiol Actions
Tryptophan hydroxylase inhibitor.
4-Chloro-DL-phenylalanine (PCPA) is an inhibitor of 5-hydroxytrytamine (5-HT) synthesis. It helps to improve the inflammation of lung tissue and remodeling pulmonary artery. PCPA can reduce the expression of tryptophan hydroxylase 1 (TPH1), matrix metalloproteinase (MMP) and pro-inflammatory factors.
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This Item | |||
|---|---|---|---|
| description - | description ≥98 atom % D, ≥99% (CP) | description 99 atom % 13C | description 97% |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form solid | form solid | form solid | form solid |
| Gene Information human ... TPH1(7166), TPH2(121278) | Gene Information - | Gene Information - | Gene Information - |
| storage temp. room temp | storage temp. - | storage temp. - | storage temp. - |
| greener alternative product characteristics Less Hazardous Chemical Syntheses | greener alternative product characteristics Less Hazardous Chemical Syntheses | greener alternative product characteristics Less Hazardous Chemical Syntheses | greener alternative product characteristics Waste Prevention |
| mp >240 °C (dec.) (lit.) | mp 270-275 °C (dec.) (lit.) | mp 270-275 °C (dec.) (lit.) | mp 72-76 °C |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Oral - Skin Sens. 1
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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For in vivo experiment, does this have to be dissolved in 1N HCL?
1 answer-
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