Merck
  • C7374
All Photos(1)

C7374

Sigma-Aldrich

CK-636

≥98% (HPLC)

All Photos(1)
Synonym(s):
CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
Empirical Formula (Hill Notation):
C16H16N2OS
CAS Number:
442632-72-6
Molecular Weight:
284.38
MDL number:
MFCD03036245
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder

color

peach to light pink

solubility

DMSO: ≥20 mg/mL

storage temp.

2-8°C

SMILES string

Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3

InChI

1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)

InChI key

ACAKNPKRLPMONU-UHFFFAOYSA-N

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CK-636 ≥98% (HPLC)

Sigma-Aldrich

C7374

CK-636

Sigma-Aldrich

Sigma-Aldrich

C9124

CK-869

CK-666 ≥98% (HPLC), powder

Sigma-Aldrich

SML0006

CK-666

SGC-CK2-1 ≥98% (HPLC)

Sigma-Aldrich

SML2951

SGC-CK2-1

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

color

peach to light pink

color

white to light gray

color

white to tan

color

white to beige

solubility

DMSO: ≥20 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: ≥25 mg/mL

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Biochem/physiol Actions

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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