C7374

CK-636

≥98% (HPLC)

• Synonym(s): CK-0944636; N-[2-(2-Methyl-1H-indol-3-yl)ethyl]-2-thiophenecarboxamide
• Empirical Formula (Hill Notation): C₁₆H₁₆N₂OS
• CAS Number: 442632-72-6
• Molecular Weight: 284.38
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD03036245
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: peach to light pink
• solubility: DMSO: ≥20 mg/mL
• storage temp.: 2-8°C
• SMILES string: Cc1[nH]c2ccccc2c1CCNC(=O)c3cccs3
• InChI: 1S/C16H16N2OS/c1-11-12(13-5-2-3-6-14(13)18-11)8-9-17-16(19)15-7-4-10-20-15/h2-7,10,18H,8-9H2,1H3,(H,17,19)
• InChI key: ACAKNPKRLPMONU-UHFFFAOYSA-N

Description

Biochem/physiol Actions

CK-636 binds between Arp2 and Arp3, where it appears to block movement of Arp2 and Arp3 into their active conformation. CK-636 inserts into the hydrophobic core of Arp3 and alters its conformation. Both classes of compounds inhibit formation of actin filament comet tails by Listeria and podosomes by monocytes.

CK-636 inhibits the activity of actin-related protein (Arp)2/3 complex; binds between Arp2 and Arp3, blocks movement of Arp2 and Arp3 into active conformations, inhibits ability to nucleate actin filaments.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable