This product is supplied as a bioactive research chemical and is not certified or qualified for use as an analytical standard. This item is not recommended for quantitative analytical applications. For analytical use, please consider Product 34124, which is specifically designated as a deoxynivalenol analytical standard. Additional information is available at the link below:
https://www.sigmaaldrich.com/product/sial/34124
D0156
Deoxynivalenol
Protein synthesis inhibitor, powder
Synonym(s):
3α,7α,15-Trihydroxy-12,13-epoxytrichothec-9-en-8-one, Vomitoxin
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Please contact Customer Service for Availability | 2 950,00 CZK |
5 mg | Please contact Customer Service for Availability | 10 100,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C15H20O6
CAS Number:
Molecular Weight:
296.32
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
powder
Product Name
Deoxynivalenol,
form
powder
Quality Segment
storage temp.
2-8°C
SMILES string
[H][C@]12O[C@]3([H])[C@H](O)C[C@@](C)([C@]34CO4)[C@@]1(CO)[C@H](O)C(=O)C(C)=C2
InChI
1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1
InChI key
LINOMUASTDIRTM-QGRHZQQGSA-N
General description
Deoxynivalenol (DON) is a natural mycotoxin found in Fusarium graminearum and Fusarium culmorum. It belongs to the B-trichothecenes family of mycotoxins.
Application
Deoxynivalenol has been used:
- as a mycotoxin to induce cytotoxicity in porcine jejunal epithelial cells and study the protective effects of Saccharomyces cerevisiae on the cell viability of host cells.
- to induce toxicity in nude mice to study the effect of probiotics (Lactobacillus rhamnosus GG (LGG) or Lactobacillus acidophilus (LA)) supplementation on host protection
- as a thyroid hormone receptor (TRβ) antagonist in cell-based luciferase reporter gene (CALUX) assay
Biochem/physiol Actions
Deoxynivalenol (DON) blocks the synthesis of DNA and RNA by inhibiting the process of translation.
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This Item | |||
|---|---|---|---|
| description - | description 100 μg/mL in acetonitrile, analytical standard | description IRMM®, certified reference material | description 1 mg/mL |
| form powder | form - | form - | form solution (ethanol: 2-propanol 95:5) |
| Quality Level 300 | Quality Level 100 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C | storage temp. −20°C |
Signal Word
Danger
Hazard Codes
Precautionary Statements
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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お世話になります。こちらの製品、「Protein synthesis inhibitor, powder」と表示があるのですが、分析用標準品として使用可能でしょうか。
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