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D1064

Dihydrokainic acid

≥98% (HPLC), GLT-1 glutamate transporter inhibitor, powder

Synonym(s):

2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid

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10 mg
Please contact Customer Service for Availability
6 760,00 CZK
5 746,00 CZK
50 mg
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23 900,00 CZK

About This Item

Empirical Formula (Hill Notation):
C10H17NO4
CAS Number:
52497-36-6
Molecular Weight:
215.25
UNSPSC Code:
12352106
PubChem Substance ID:
24277981
NACRES:
NA.77
MDL number:
MFCD03412037
Assay:
≥98% (HPLC)
Form:
powder

5 746,00 CZK

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Product Name

Dihydrokainic acid, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

solubility

H2O: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

InChI

1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1

InChI key

JQPDCKOQOOQUSC-OOZYFLPDSA-N

Gene Information

Application

Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes and glial cells. It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).

Biochem/physiol Actions

Dihydrokainic favors neuronal cell death. It modulates anxiety and depression behaviors.
Dihydrokainic acid is a selective GLT-1 glutamate transporter inhibitor; weak inhibitor of AMPA/kainate glutamic acid receptors at high concentrations.
Dihydrokainic acid is a selective inhibitor of the GLT-1 glutamate transporter. At higher concentrations, dihydrokainate is a weak inhibitor of AMPA/kainate glutamic acid receptors.

Features and Benefits

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
420318K2389A6816
Dihydrokainic acid ≥98% (HPLC), powder

Sigma-Aldrich

D1064

Dihydrokainic acid

Kainic Acid An excitatory amino acid receptor agonist selective for the kainate receptor subtype (Ki = 21 nM for ³H-kainate binding in rat striatum).

Sigma-Aldrich

420318

Kainic Acid

Kainic acid monohydrate ≥98% (HPLC), from Digenea simplex

Sigma-Aldrich

K2389

Kainic acid monohydrate

(±)-AMPA solid

Sigma-Aldrich

A6816

(±)-AMPA

description

≥98% (HPLC), powder

description

An excitatory amino acid receptor agonist selective for the kainate receptor subtype (Ki = 21 nM for ³H-kainate binding in rat striatum).

description

≥98% (HPLC), from Digenea simplex

description

solid

form

powder

form

solid

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

H2O: >10 mg/mL

solubility

dilute base: 10 mg/mL, water: 10 mg/mL

solubility

H2O: >10 mg/mL

solubility

H2O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 1 M HCl: 50 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL

Gene Information

human ... SLC1A1(6505), SLC1A2(6506), SLC1A3(6507)
rat ... Slc1a2(29482), Slc1a3(29483)

Gene Information

-

Gene Information

-

Gene Information

rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Slc1a1(25550), Slc1a2(29482), Slc1a3(29483)

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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