D3572

Dipeptidyl Peptidase IV Inhibitor IV

• Synonym(s): (S)-1-(4-Methyl-1-(2-pyrimidinyl)-4-piperidylamino)acetyl-2-pyrrolidinecarbonitrile, K579
• Empirical Formula (Hill Notation): C₁₇H₂₄N₆O
• Molecular Weight: 328.41
• NACRES: NA.77
• UNSPSC Code: 12352202
• Assay: ≥97% (HPLC)

Properties

• assay: ≥97% (HPLC)
• Quality Segment: 200
• form: solid
• storage temp.: 2-8°C

Description

General description

Dipeptidyl Peptidase IV Inhibitor IV, also known as K579 ((S)-1-[4-methyl-1-(2-pyrimidinyl)-4-piperidylamino]acetyl-2-pyrrolidinecarbonitrile), is orally available. It has a formula weight of 339.39 g/mol.

Biochem/physiol Actions

Dipeptidyl peptidase IV (DPP IV) is a key enzyme involved in the regulation of incretin hormone levels in the gastrointestinal tract. Incretin hormones, such as glucagon like peptide (GLP-1) and glucose-dependent insulinotropic hormone (GIP) / gastric inhibitory peptide, cause the glucose stimulated release of insulin. This allows the endocrine system to preemptively stimulate release insulin in response to ingestion of high sugar foods. Type 2 diabetics demonstrate a greatly reduced incretin induced insulin release response.
This response in hyperglycemic conditions is counterbalanced by the rapid rate of degradation of these incretin hormones by dipeptidyl peptidase IV in normal conditions. Inhibition of dipeptidyl peptidase IV results in longer lifetime of the incretin hormones in the GI tract and thus prolonged stimulation of insulin production. Specific dipeptidyl peptidase inhibitors are actively being explored as drug targets for treating type 2 diabetes and several candidates are actively in clinical trial.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable