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D7385

Demecolcine

≥98% (HPLC)

Synonym(s):

N-Deacetyl-N-methylcolchicine

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Size/SKUAvailabilityPrice
5 mg
Please contact Customer Service for Availability
8 400,00 CZK
10 mg
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13 600,00 CZK
50 mg
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45 200,00 CZK

About This Item

Empirical Formula (Hill Notation):
C21H25NO5
CAS Number:
477-30-5
Molecular Weight:
371.43
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24894128
EC Number:
207-514-6
Beilstein/REAXYS Number:
2822892
MDL number:
MFCD00075459

8 400,00 CZK

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Quality Segment

assay

≥98% (HPLC)

form

powder

mp

184 °C

solubility

chloroform: 10 mg/mL, ethanol: soluble

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

2-8°C

SMILES string

CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2C3=CC=C(OC)C(=O)C=C13

InChI

1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1

InChI key

NNJPGOLRFBJNIW-HNNXBMFYSA-N

Application

Demecolcine has been used as a microtubule depolymerizing agent. It has also been used to inhibit mitotic division.

Biochem/physiol Actions

Often in karyotyping and cell cycle research it is desirable to increase the yield of mitotic cells in a particular phase of the cell cycle. This can be achieved in a variety of ways with the most popular being the use of a cell cycle synchronizing agent such as demecolcine. Demecolcine will arrest cells in metaphase with no remarkable effect on the biochemical events in mitotic cells or in synchronized G1 and S phase cells. White blood cells are often treated with demecolcine to arrest cells in metaphase.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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This Item
10295892001D1925CRM36147
Demecolcine ≥98% (HPLC)

Sigma-Aldrich

D7385

Demecolcine

Colcemid solution, suitable for blocking, sterile; 0.2 μm filtered

Roche

10295892001

Colcemid

Demecolcine solution 10 μg/mL in HBSS, ACF Qualified, BioXtra

Sigma-Aldrich

D1925

Demecolcine solution

Mecoprop certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

Supelco

CRM36147

Mecoprop

description

≥98% (HPLC)

description

solution, suitable for blocking, sterile; 0.2 μm filtered

description

10 μg/mL in HBSS, ACF Qualified, BioXtra

description

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

assay

≥98% (HPLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

-

Quality Level

400

Quality Level

300

form

powder

form

solution

form

liquid

form

-

solubility

chloroform: 10 mg/mL, ethanol: soluble

solubility

water: miscible

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mp

184 °C

mp

-

mp

-

mp

-

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Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H300

Hazard Classifications

Acute Tox. 2 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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