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Diazoxide

Name: Diazoxide
Brand: SIGMA
Price: 3290 CZK

≥98% (TLC), powder, ATP-sensitive K⁺ channel activator

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Synonym(s):

7-Chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

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Size/SKU	Availability	Price
250 mg	Please contact Customer Service for Availability	3 290,00 CZK
1 g	Please contact Customer Service for Availability	8 460,00 CZK
5 g	Please contact Customer Service for Availability	32 300,00 CZK

About This Item

Empirical Formula (Hill Notation):

C₈H₇ClN₂O₂S

CAS Number:

364-98-7

Molecular Weight:

230.67

NACRES:

NA.77

PubChem Substance ID:

24277831

UNSPSC Code:

12352119

EC Number:

206-668-1

MDL number:

MFCD00078578

Form:

powder

3 290,00 CZK

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Properties

Product Name

Diazoxide,

form

powder

Quality Segment

100

solubility

0.1 M NaOH: soluble, H₂O: insoluble, methanol: soluble

originator

Schering Plough

SMILES string

CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1

InChI

1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)

InChI key

GDLBFKVLRPITMI-UHFFFAOYSA-N

Gene Information

human ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778)
mouse ... Kcnj1(56379), Kcnj11(16514)
rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)

Description

General description

Diazoxide is a nondiuretic benzothiadiazine, which is used for the treatment of hypoglycemia, von Gierke′s disease, acute and malignant hypertension. It acts as a beta cell K_ATP channel opener. Diazoxide prevents the secretion of insulin.

Application

Diazoxide has been used for diazoxide infusion. It has also been used to prevent depolarization for K⁺-induced exocytosis.

Biochem/physiol Actions

Selective ATP-sensitive K⁺ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item	D0950000	1186000	C4911
Sigma-Aldrich D9035 Diazoxide	D0950000 Diazoxide	USP 1186000 Diazoxide	Sigma-Aldrich C4911 Chlorothiazide
description -	description European Pharmacopoeia (EP) Reference Standard	description United States Pharmacopeia (USP) Reference Standard	description thiazide diuretic
form powder	form -	form -	form powder
Quality Level 100	Quality Level -	Quality Level -	Quality Level 100
solubility 0.1 M NaOH: soluble, methanol: soluble, H₂O: insoluble	solubility -	solubility -	solubility DMF: 50 mg/mL, clear, colorless to very faintly yellow
originator Schering Plough	originator -	originator -	originator -
Gene Information human ... KCNA1(3736), KCNJ11(3767), KCNJ8(3764), KCNMA1(3778) mouse ... Kcnj1(56379), Kcnj11(16514) rat ... Gria1(50592), Kcna1(24520), Kcnj1(24521), Kcnj11(83535), Kcnj8(25472)	Gene Information human ... KCNJ11(3767), KCNJ8(3764)	Gene Information human ... KCNJ11(3767), KCNJ8(3764)	Gene Information human ... CA1(759), CA4(762), SLC12A3(6559)

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302,H315,H319,H335

Precautionary Statements

P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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