E5750

Ergocalciferol

40,000,000 USP units/g

• Synonym(s): Calciferol, Ercalciol, Ergosterol irradiated, Irradiated ergosterol, Vitamin D₂
• Empirical Formula (Hill Notation): C₂₈H₄₄O
• CAS Number: 50-14-6
• Molecular Weight: 396.65
• NACRES: NA.79
• PubChem Substance ID: 24894344
• eCl@ss: 34058017
• UNSPSC Code: 12352205
• EC Number: 200-014-9
• MDL number: MFCD00166988
• Beilstein/REAXYS Number: 1916682

Properties

• biological source: synthetic (organic)
• Quality Segment: 200
• assay: ≥97%
• form: powder
• specific activity: 40,000,000 USP units/g
• technique(s): HPLC: suitable
• color: white to off-white
• mp: 114-118 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CCC/2)([H])C2=C\C=C(C[C@@H](O)CC3)/C3=C
• InChI: 1S/C28H44O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-20,22,25-27,29H,4,7-8,11,14-18H2,1-3,5-6H3/b10-9+,23-12+,24-13-/t20-,22+,25-,26+,27-,28+/m0/s1
• InChI key: MECHNRXZTMCUDQ-RKHKHRCZSA-N
• Gene Information: human ... VDR(7421)

Description

General description

Vitamin D₂ or ergocalciferol is available through dietary supplements or plant sources. It is a provitamin, which is fat-soluble.

Application

Ergocalciferol has been used as a component of the diet for rats, to study its bioavailability from ultraviolet-irradiated D2-rich yeast. It has also been used as a standard for identification and quantification of vitamins, as part of a study to determine the nutritional composition of food fishes.

Biochem/physiol Actions

Ergocalciferol (vitamin D₂) and 25-Hydroxycholecalciferol (vitamin D₃) are the two forms of vitamin D, which are activated in vivo by hydroxylation. Vitamin D2 and D3 may be used in a wide range of studies to assess their effects on function such as immune function and calcium homeostasis.

Ergocalciferol is used for antirachitic treatment. Vitamin D has an active role in bone mineralization. Severe deficiency of this vitamin has been associated with osteomalacia and rickets.

Packaging

Sealed ampule.

Preparation Note

1 USP unit = 1 I.U.

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Codes: H301 + H311,H330,H372
• Precautionary Statements: P260 - P264 - P280 - P302 + P352 + P312 - P304 + P340 + P310 - P314
• Hazard Classifications: Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - STOT RE 1 Oral
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges