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Equilin

Name: Equilin
Brand: SIGMA
Price: 4720 CZK

synthetic (organic), ≥98% (HPLC), 17β-HSD1 inhibitor, powder

Synonym(s):

1,3,5(10),7-Estratetraen-3-ol-17-one, 3-Hydroxy-1,3,5(10),7-estratetraen-17-one, 7-Dehydroestrone

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Size/SKU	Availability	Price
100 mg	Please contact Customer Service for Availability	4 720,00 CZK
1 g	Please contact Customer Service for Availability	28 700,00 CZK

About This Item

Empirical Formula (Hill Notation):

C₁₈H₂₀O₂

CAS Number:

474-86-2

Molecular Weight:

268.35

NACRES:

NA.77

PubChem Substance ID:

24894666

UNSPSC Code:

12352200

EC Number:

207-488-6

MDL number:

MFCD00046223

Beilstein/REAXYS Number:

2624302

Assay:

≥98% (HPLC)

Form:

powder

4 720,00 CZK

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Properties

Product Name

Equilin,

biological source

synthetic (organic)

Quality Segment

100

sterility

non-sterile

assay

≥98% (HPLC)

form

powder

technique(s)

inhibition assay: suitable

mp

238-240 °C (lit.)

solubility

chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12CC[C@H]3C(=CCc4cc(O)ccc34)[C@@H]1CCC2=O

InChI

1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1

InChI key

WKRLQDKEXYKHJB-HFTRVMKXSA-N

Description

Biochem/physiol Actions

Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy. It is synthesized in the microsomes of mare placenta. It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis. In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.

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1 of 1

This Item	1238002	Y0000052	492531
Sigma-Aldrich E8126 Equilin	USP 1238002 Equilin	Y0000052 Equilin	Sigma-Aldrich 492531 Equilin-2,4,16,16-d₄ 3-sulfate sodium salt
description -	description United States Pharmacopeia (USP) Reference Standard	description European Pharmacopoeia (EP) Reference Standard	description ≥97 atom % D, ≥96% (CP), contains 50% TRIS-d₅ as stabilizer
assay ≥98% (HPLC)	assay -	assay -	assay ≥96% (CP)
form powder	form -	form -	form solid
Quality Level 100	Quality Level -	Quality Level -	Quality Level 200
storage temp. room temp	storage temp. 2-8°C	storage temp. −20°C	storage temp. -
solubility chloroform: methanol (1:1): 40 mg/mL, clear, colorless to faintly yellow	solubility -	solubility -	solubility -
shipped in ambient	shipped in -	shipped in -	shipped in -

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Pictograms

GHS08

Signal Word

Warning

Hazard Codes

H351,H361fd,H362

Precautionary Statements

P202 - P260 - P263 - P264 - P270 - P308 + P313

Hazard Classifications

Carc. 2 - Lact. - Repr. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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