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F3771

Fumonisin B₂

From Fusarium sp. (Fusarium moniliforme), ≥96% (TLC), Sphingosine N-acyltransferase inhibitor, powder

Synonym(s):

FB2, Fumonisin B2

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Size/SKUAvailabilityPrice
1 mg
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12 500,00 CZK
10 mg
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94 000,00 CZK

About This Item

Empirical Formula (Hill Notation):
C34H59NO14
CAS Number:
Molecular Weight:
705.83
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:

12 500,00 CZK


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Product Name

Fumonisin B2 from Fusarium moniliforme, sphingosine N-acyltransferase inhibitor

biological source

Fusarium sp. (Fusarium moniliforme)

Quality Segment

assay

≥96% (TLC)

form

powder

solubility

methanol: 10 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

CCCCC(C)C(OC(=O)CC(CC(O)=O)C(O)=O)C(CC(C)CCCCCCC(O)CC(O)C(C)N)OC(=O)CC(CC(O)=O)C(O)=O

InChI

1S/C34H59NO14/c1-5-6-12-21(3)32(49-31(43)18-24(34(46)47)16-29(40)41)27(48-30(42)17-23(33(44)45)15-28(38)39)14-20(2)11-9-7-8-10-13-25(36)19-26(37)22(4)35/h20-27,32,36-37H,5-19,35H2,1-4H3,(H,38,39)(H,40,41)(H,44,45)(H,46,47)

InChI key

UXDPXZQHTDAXOZ-UHFFFAOYSA-N

General description

Mycotoxin originally isolated from Fusarium sp, which grows on corn. Produces neural tube defects and craniofacial abnormalities in fetuses. Many strains of Aspergillus niger growing naturally on grapes are capable of producing fumonisin B2, so it is now a concern for human consumption of grapes, raisins, and wine.
Fumonisin B2 (FB2) is a diester of tricarballylic acid and polyhydric alcohols.. Fumonisins B2 (FB2) does not have one or more hydroxyl groups at the C5 or C10 positions.

Application

Fumonisin B2 (FB2) from Fusarium moniliforme has been used:
  • as a standard for the detection of FB2 by high performance liquid chromatography (HPLC) in corn based food products
  • used as standard in the determination of fumonisin B1 and B2 in corn and corn-based products by high-performance liquid chromatography
  • as a standard in the determination of mycotoxins by HPLC

Biochem/physiol Actions

Inhibitor of sphingosine N-acyltransferase. Blocks the formation of ceramide from sphingosine.

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1 of 1

This Item
344852F781734142
description

sphingosine N-acyltransferase inhibitor

description

Structural analog of Fumonisin B1 that has higher cytotoxicity and specific binding to primary rat hepatocytes than fumonisin B1.

description

1.4 mM in DMSO

description

~50 μg/mL in acetonitrile: water (50:50), analytical standard

biological source

Fusarium sp. (Fusarium moniliforme)

biological source

-

biological source

-

biological source

-

assay

≥96% (TLC)

assay

≥98% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

100

Quality Level

200

Quality Level

100

form

powder

form

solid

form

-

form

-

solubility

methanol: 10 mg/mL, clear, colorless to faintly yellow

solubility

methanol: 5 mg/mL

solubility

-

solubility

-

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C


Pictograms

Health hazard

Signal Word

Warning

Hazard Codes

Hazard Classifications

Carc. 2

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges



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