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Fibroblast Growth Factor-5 human

Name: Fibroblast Growth Factor-5 human
Brand: SIGMA
Price: 11900 CZK

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE and N-terminal analysis)

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Synonym(s):

hFGF-5, FGF-5

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Size/SKU	Availability	Price
50 μg	Please contact Customer Service for Availability	11 900,00 CZK

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00212946

11 900,00 CZK

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Properties

biological source

human

Quality Segment

100

recombinant

expressed in E. coli

assay

≥97% (SDS-PAGE and N-terminal analysis)

form

lyophilized powder

potency

0.1-15.0 ng/mL

mol wt

27 kDa

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P12034

storage temp.

−20°C

Gene Information

human ... FGF5(2250)

Description

Application

Fibroblast growth factor-5 human has been used for the induction of differentiation in E14Tg2a and 46C parental mouse ES (embryonic stem) cell lines, Fgf4^+/- (clone 342) ,Fgf4^-/- (clone FD6) ES cells and Erk2^+/- ES cells and Erk2^-/- ES cell lines.

Biochem/physiol Actions

FGF5 (fibroblast growth factor 5) regulates hair growth cycle, and its inactivation in mice leads to angora phenotype. In the peripheral nervous system, it acts as a muscle-derived trophic factor for motor neurons. In vivo it demonstrates neurotrophic activity, and in vitro it influences astroglial characteristics. It functions as an oncogene in glioblastoma due to its autocrine and paracrine functions. Its expression is elevated in human astrocytic brain tumours, which is linked to increased malignancy. It causes the regression of hair follicles, and thus, controls the length of hair in humans. It might have potential as a therapeutic target to control the growth of eyelashes.

Physical form

Lyophilized from a 0.2 μm filtered solution in 10mM MOPS, 50 mM NaSO₄, 0.5 mM EDTA, 0.5 mM DTT and 5% trehalose, pH 7.0 containing 50 μg BSA per 1 μg cytokine.

Analysis Note

The biological activity is tested in culture with quiescent NR6R-3T3 fibroblasts.

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This Item	F5542	F8424	F3133
Sigma-Aldrich F4537 Fibroblast Growth Factor-5 human	Sigma-Aldrich F5542 Fibroblast Growth Factor-Acidic human	Sigma-Aldrich F8424 Fibroblast Growth Factor-4 human	Sigma-Aldrich F3133 Fibroblast Growth Factor from bovine pituitary
description recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE and N-terminal analysis)	description FGF-Acidic, recombinant, expressed in E. coli, suitable for cell culture	description FGF-4, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture	description suitable for cell culture
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
assay ≥97% (SDS-PAGE and N-terminal analysis)	assay ≥97% (SDS-PAGE)	assay ≥95% (SDS-PAGE and HPLC)	assay -
recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant expressed in E. coli	recombinant -
biological source human	biological source human	biological source human	biological source bovine pituitary glands
Quality Level 100	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Storage Class

11 - Combustible Solids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

Signal Word

Danger

Hazard Codes

EUH451

Precautionary Statements

P201 - P202 - P273 - P391 - P501

Hazard Classifications

vPvM

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