F5013

5-Fluoroorotic acid hydrate

≥98%

• Synonym(s): 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic acid, 5-Fluorouracil-4-carboxylic acid
• Empirical Formula (Hill Notation): C₅H₃FN₂O₄ · xH₂O
• CAS Number: 207291-81-4
• Molecular Weight: 174.09 (anhydrous basis)
• NACRES: NA.32
• PubChem Substance ID: 24894877
• UNSPSC Code: 12352204
• EC Number: 211-876-0
• MDL number: MFCD00150658

Properties

• biological source: synthetic
• Quality Segment: 200
• assay: ≥98%
• form: powder
• technique(s): cell culture | plant: suitable
• mp: 278 °C (dec.) (lit.)
• solubility: 4 M NH₄OH: 50 mg/mL, clear, colorless to light yellow
• storage temp.: −20°C
• SMILES string: OC(C(NC(N1)=O)=C(F)C1=O)=O.[H]O[H]
• InChI: 1S/C5H3FN2O4.H2O/c6-1-2(4(10)11)7-5(12)8-3(1)9;/h(H,10,11)(H2,7,8,9,12);1H2
• InChI key: LODRRYMGPWQCTR-UHFFFAOYSA-N

Description

Application

5-Fluoroorotic acid hydrate has also been used as a counter-selection agent to screen L. lactis (multi) peptidase knockout mutants and C. albicans. It has been used in synthesis of 5-fluoroorotidine 5′-monophosphate (FOMP).

Useful in the selection of orotidine-5′-phosphate decarboxylase mutants of Saccharomyces cerevisiae.

Biochem/physiol Actions

5-Fluoroorotic acid is a selective inhibitor of rRNA synthesis in mammals.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves