F5053

Flavin-Containing Monooxygenase-3, Microsomes human

recombinant, expressed in baculovirus infected insect cells, buffered aqueous solution

• Synonym(s): FMO-3
• EC Number: 1.14.13.8 (BRENDA, IUBMB)
• NACRES: NA.54
• UNSPSC Code: 12352204
• eCl@ss: 32160703
• Recombinant: expressed in baculovirus infected insect cells

Properties

• recombinant: expressed in baculovirus infected insect cells
• Quality Segment: 200
• form: buffered aqueous solution
• mol wt: 55-60 kDa
• packaging: vial of 2.5 mg
• UniProt accession no.: P31513
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... FMO3(2328)

Description

General description

Flavin-Containing Monooxygenase-3 (FMO3) is a member of the flavin-containing monooxygenase (FMO) family of enzymes. It is highly expressed in the human liver.

Application

FMO3 is the major human hepatic form.

Biochem/physiol Actions

Flavin-Containing Monooxygenase-3 (FMO3) facilitates the oxidization of several drugs, chemicals, and xenobiotics. Human FMO3 is also involved in the synthesis of N-oxide of trimethylamine (TMAO) from trimethylamine (TMA). Mutations in the FMO3 gene are associated with trimethylaminuria or fish odor syndrome. Deficiency of the FMO3 gene results in lower plasma TMAO levels, which may reduce the risk of developing atherosclerosis and thrombosis.

Physical form

Solution in 100 mM potassium phosphate buffer, pH 7.4

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)