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FGFR3 (397-end), active, GST tagged human

Name: FGFR3 (397-end), active, GST tagged human
Brand: SIGMA
Price: 13000 CZK

PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

Eph receptor tyrosine kinase, growth hormone receptor, ACH, CD333, CEK2, HSFGFR3EX, JTK4

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Size/SKU	Availability	Price
10 μg	Please contact Customer Service for Availability	13 000,00 CZK

About This Item

NACRES:

NA.32

UNSPSC Code:

51111800

Form:

buffered aqueous glycerol solution

Assay:

≥70% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected Sf9 cells

Mol wt:

~73 kDa

13 000,00 CZK

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Properties

biological source

human

Quality Segment

200

recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO^® Kinase

assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

95-129 nmol/min·mg

mol wt

~73 kDa

packaging

pkg of 10 μg

technique(s)

cell based assay: suitable

solubility

water: soluble

Protein ID accession no.

NM 000142

UniProt accession no.

P22607

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... FGFR3(2261)

Description

General description

Research area: Cancer

FGFR3 (fibroblast growth factor receptor 3) is a receptor tyrosine kinase (RTK) and belongs to the FGFR subfamily. This subfamily includes four members namely, FGFR1, FGFR2, FGFR3, and FGFR4. It contains a ligand-binding region in its exoplasmic domain, a single transmembrane region, and a tyrosine kinase domain in its intracellular domain.FGFR3 has a strong affinity for canonical FGF ligands.

Biochem/physiol Actions

FGFR3 (fibroblast growth factor receptor 3) plays an essential role in the signaling pathways during embryogenesis and angiogenesis. This gene is either mutated or up-regulated in multiple myeloma, cervical carcinoma and nonmuscle-invasive urothelial carcinoma (UC) of the bladder.Apart from this, certain mutations in FGFR3 are also known to be linked with skeletal disorders such as various forms of dwarfism. FGFR3 also plays hepatoprotective function during liver damage.

Physical form

Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

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This Item	SAB3501041	SAB5702794	SRP5030
Sigma-Aldrich F7930 FGFR3 (397-end), active, GST tagged human	Sigma-Aldrich SAB3501041 Anti-FGFR3 antibody produced in rabbit	Sigma-Aldrich SAB5702794 Anti-FGFR3 Antibody, clone 2V1Z6, Rabbit Monoclonal	Sigma-Aldrich SRP5030 FGFR2 (285-end), active, GST tagged human
description PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution	description affinity isolated antibody	description -	description PRECISIO^® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE), buffered aqueous glycerol solution
recombinant expressed in baculovirus infected Sf9 cells	recombinant -	recombinant -	recombinant expressed in baculovirus infected Sf9 cells
biological source human	biological source rabbit	biological source rabbit	biological source -
assay ≥70% (SDS-PAGE)	assay -	assay -	assay ≥80% (SDS-PAGE)
technique(s) cell based assay: suitable	technique(s) immunohistochemistry: suitable, immunofluorescence: suitable, ELISA: suitable, immunoblotting: suitable	technique(s) immunohistochemistry: 1:50 - 1:200, western blot: 1:500 - 1:2000	technique(s) -
mol wt ~73 kDa	mol wt predicted mol wt 89 kDa	mol wt 110 kDa	mol wt ~72 kDa
form buffered aqueous glycerol solution	form buffered aqueous solution	form liquid	form buffered aqueous glycerol solution

Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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