M265

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01865097
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC (f), IP, WB
• Citations: 12

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• mol wt: antigen 180 kDa
• species reactivity: rat, human, mouse
• technique(s): immunohistochemistry (frozen sections): 1:1,000, immunoprecipitation (IP): 3 μL using 200 μg of rat brain, western blot: 1 μg/mL using ³⁵S-Protein A (with ECL dilutions may be higher)
• UniProt accession no.: Q13224
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... GRIN2B(2904) ; mouse ... Grin2b(14812) ; rat ... Grin2b(24410)

Description

General description

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) codes for N-methyl D-aspartate receptor subtype 2B (GluN2B). It is an important constituent of the N-methyl D-aspartate receptor protein. GRIN2B gene is located on human chromosome 12p13.1.

Immunogen

C-terminal portion of NR2B (amino acids 984-1104).

Application

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody is suitable for use in immunohistochemistry (1:1,000 dilution, using frozen sections), immunoprecipitation (3 μL using 200 μg of rat brain), and indirect ELISA. The antibody may also be used for western blot (1 μg/mL using (35S)-Protein A) and immunoblot (180 kDa).

Anti-Glutamate Receptor NMDAR2B (NR2B) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Glutamate ionotropic receptor N-methyl-D-aspartate (NMDA) type subunit 2B (GRIN2B) plays a key role in synaptic plasticity, language acquisition, neural pattern formation and short-term memory. Mutations on GRIN2B gene results in Parkinson′s disease, schizophrenia, bipolar disorder, Alzheimer′s disease and obsessive-compulsive disorder.

The functional N-Methyl-D-Aspartate (NMDA) receptor complex consists of a NMDAR1 (NR1) subunit and atleast one NMDAR2 subunit ranging from NR2A-NR2D. These receptor complexes have been implicated in cochlear functions and neuronal plasticity. The C-terminal end of NR2B receptor may regulate synaptic localization.

Physical form

Lyophilized from ammonium bicarbonate (5 mM).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, type N95 (US)