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P3371

Penfluridol

≥97% (HPLC), powder

Synonym(s):

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

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Size/SKUAvailabilityPrice
50 mg
Please contact Customer Service for Availability
4 530,00 CZK

About This Item

Empirical Formula (Hill Notation):
C28H27ClF5NO
CAS Number:
Molecular Weight:
523.97
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
248-074-5
MDL number:
Assay:
≥97% (HPLC)
Form:
powder

4 530,00 CZK


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Quality Segment

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL, H2O: insoluble

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

Application

Penfluridol has been used as an antipsychotic agent:
  • to study its antimetastatic effect on triple-negative breast cancer cells
  • to study its effects on the growth of glioblastoma cell lines,
  • to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.
T-type Ca2+ channel blocker; antipsychotic

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
CRM68087SML284145337
description

≥97% (HPLC), powder

description

certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

description

≥98% (HPLC)

description

PESTANAL®, analytical standard

assay

≥97% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

-

form

powder

form

-

form

powder

form

-

Quality Level

100

Quality Level

300

Quality Level

100

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

solubility

H2O: insoluble, DMSO: >20 mg/mL

solubility

-

solubility

DMSO: 2 mg/mL, clear

solubility

-

color

white

color

-

color

white to beige

color

-


Pictograms

Skull and crossbones

Signal Word

Danger

Hazard Codes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

PPE (personal protective equipment)

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges



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