P4871

Anti-Purinergic Receptor P2Y₁₂ antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• Synonym(s): Anti-ADPG-R, Anti-BDPLT8, Anti-HORK3, Anti-P2T(AC), Anti-P2Y(12)R, Anti-P2Y(AC), Anti-P2Y(ADP), Anti-P2Y(cyc), Anti-P2Y12
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD04975335
• eCl@ss: 38150101
• Conjugate: unconjugated
• Clone: polyclonal
• Application: IHC, WB
• Citations: 9

Properties

• biological source: rabbit
• Quality Segment: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: human, mouse, rat
• technique(s): immunohistochemistry: suitable using mouse brain sections, western blot: 1:200 using rat brain membranes or human platelets
• UniProt accession no.: Q9H244
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... P2RY12(64805) ; mouse ... P2ry12(70839) ; rat ... P2ry12(64803)

Description

General description

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 is a G-protein-coupled receptor. The gene encoding it is localized on human chromosome 3q25.1.

Immunogen

peptide corresponding to amino acid residues 125-142 of human P2Y₁₂. This epitope is highly homologous in rat and mouse (16/18 residues identical).

Application

Anti-Purinergic Receptor P2Y12 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Purinergic receptor or platelet adenosine 5′-diphosphate (ADP) receptor P2Y12 has a role in platelet aggregation induced by ADP. Dysfunctional mutations in the protein have been linked with bleeding disorders. Studies have indicated that mice deficient in the P2Y12 receptor show decreased tumor metastasis.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Hazard Codes: H412
• Precautionary Statements: P273
• Hazard Classifications: Aquatic Chronic 3
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable