PLA0100

Rabbit anti-MLL1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

• Synonym(s): ALL-1, CDK6/MLL fusion protein, CXXC-type zinc finger protein 7, CXXC7, HRX, HTRX1, MLL, MLL-AF4 der(11) fusion protein, MLL-AF9, MLL/ENL fusion protein, MLL/GAS7, MLL/GAS7 fusion protein, MLL/GMPS fusion protein, MLL/hCDCrel fusion protein, MLL1, MLL1A, Myeloid/lymphoid or mixed-lineage leukemia, TET1-MLL, TRX1, WDSTS, lysine (K)-specific methyltransferase 2A, lysine N-methyltransferase 2A, mixed lineage leukemia 1, rearranged MLL protein, trithorax-like protein, zinc finger protein HRX
• NACRES: NA.43
• UNSPSC Code: 12352203
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ChIP, IP, WB
• Citations: 4

Properties

• biological source: rabbit
• Quality Segment: 100
• conjugate: unconjugated
• antibody form: affinity purified immunoglobulin
• antibody product type: primary antibodies
• clone: polyclonal
• species reactivity: human
• technique(s): ChIP: 1- 5 μg, immunoprecipitation (IP): 2-5 μg/mg, western blot: 1:2,000-1:10,000
• accession no.: Q03164
• shipped in: wet ice
• storage temp.: 2-8°C
• target post-translational modification: unmodified
• Gene Information: rabbit ... MLL1(4297)

Description

General description

MLL1 (mixed-lineage leukemia) gene is also referred as KMT2A (lysine methyltransferase 2A) and is located on human chromosome locus 11q23.3.

Immunogen

The epitope recognized by PLA0100 maps to a region between residues 2725 and 2775 of human myeloid/lymphoid or mixed-lineage leukemia 1 using the number given in Swiss-Prot entry Q03164 (GeneID 4297).

Biochem/physiol Actions

MLL1 (mixed-lineage leukemia) is a histone methyltransferase and has a role in embryogenesis and hematopoiesis. MLL1 is a transcriptional co-activator and regulates epigenetic gene expression through chromatin modification. MLL1 is associated with NF-κB (nuclear factor kappa B) pathway- induced brain tumor proliferation. On the other hand, MLL1 is known to prevent metastasis and invasion in cervical cancer.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

MLL1 (mixed lineage leukemia 1) has been found to participate in a multitude of chromosomal translocations that are associated with a variety of hematologic malignancies. MLL1 functions as a transcriptional regulator and plays and important role in HOX gene expression during embryonic development.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable