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SML0944

NK-252

≥98% (HPLC)

Synonym(s):

N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-N′-(2-pyridinylmethyl)-urea

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
8 790,00 CZK

About This Item

Empirical Formula (Hill Notation):
C13H11N5O3
CAS Number:
Molecular Weight:
285.26
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

8 790,00 CZK


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

N(Cc3ncccc3)C(=O)Nc1nnc([o]1)c2[o]ccc2

InChI

1S/C13H11N5O3/c19-12(15-8-9-4-1-2-6-14-9)16-13-18-17-11(21-13)10-5-3-7-20-10/h1-7H,8H2,(H2,15,16,18,19)

InChI key

FNSCFQXZZNCDAI-UHFFFAOYSA-N

Biochem/physiol Actions

NK-252 is a very potent, specific activator of the transcription factor Nrf2, which activates antioxidant-associated genes. NK-252 induces expression of an antioxidant response element promoter driven reporter gene, and protects Huh-7 liver cells against H202 induced cytotoxicity.
NK-252 is a very potent, specific activator of the transcription factor Nrf2.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
420305K2015
description

≥98% (HPLC)

description

A cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase C (IC50 = 2.45 µM) and protein kinase A (IC50 = 25.7 µM).

description

Ready Made Solution, from Nonomuraea longicatena, >98%

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

>98%

form

powder

form

solid

form

solution

Quality Level

100

Quality Level

100

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 5 mg/mL, methanol: soluble

solubility

-

color

white to beige

color

off-white

color

-


Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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