SML2134

Finafloxacin

Name: Finafloxacin
Brand: SIGMA
Price: 2159 CZK

≥95% (HPLC)

Synonym(s):

8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

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10 MG

CZK 2,159.00

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CZK 8,755.00

CZK 2,159.00

List PriceCZK 2,540.00Save 15%

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About This Item

Empirical Formula (Hill Notation):

C₂₀H₁₉FN₄O₄

CAS Number:

209342-40-5

Molecular Weight:

398.39

UNSPSC Code:

12352200

NACRES:

NA.77

Key Documents

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Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

Fc1cc2c([n](cc([c]2=O)C(=O)O)C5CC5)c(c1N3C[C@@H]4NCCO[C@H]4C3)C#N

InChI

1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1

InChI key

FYMHQCNFKNMJAV-HOTGVXAUSA-N

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Show Differences

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This Item	SML1608	SML2795	SML1581
Sigma-Aldrich SML2134 Finafloxacin	Sigma-Aldrich SML1608 Besifloxacin hydrochloride	Sigma-Aldrich SML2795 IMP-1700	Sigma-Aldrich SML1581 Moxifloxacin hydrochloride
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form powder
storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C
solubility DMSO: 2 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear	solubility H₂O: 5 mg/mL, clear (warmed)
color white to beige	color white to light brown	color white to beige	color white to beige

Biochem/physiol Actions

Finafloxacin is a fluoroquinolone antibiotic approved by the FDA in 2014 for treating swimmer′s ear. Its mechanism of action involves the inhibition of bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV

Fluoroquinolone antibiotic

Pictograms

GHS08

Signal Word

Danger

Hazard Statements

H340,H361f

Precautionary Statements

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Muta. 1B - Repr. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Finafloxacin overcomes Burkholderia pseudomallei efflux-mediated fluoroquinolone resistance.

Linnell B Randall et al.

The Journal of antimicrobial chemotherapy, 72(4), 1258-1260 (2017-01-01)

In vitro spectrum of activity of finafloxacin, a novel, pH-activated fluoroquinolone, under standard and acidic conditions.

Will Stubbings et al.

Antimicrobial agents and chemotherapy, 55(9), 4394-4397 (2011-06-29)

Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim of this study was to define the in vitro pH-activity relationship. Finafloxacin exhibited optimal antibacterial activity between pH 5.0 and 6.0 at which MICs were

High Efficacy of Finafloxacin on Helicobacter pylori Isolates at pH 5.0 Compared with That of Other Fluoroquinolones.

Jung Won Lee et al.

Antimicrobial agents and chemotherapy, 59(12), 7629-7636 (2015-09-30)

Finafloxacin is a novel fluoroquinolone with improved antimicrobial efficacy, especially in an acidic environment. The efficacy of finafloxacin for the inhibition of Helicobacter pylori infection was compared with the efficacies of levofloxacin and moxifloxacin at neutral and acidic pH. The

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Finafloxacin