SML2267
GeA-69
≥98% (HPLC)
Synonym(s):
N-[2-(9H-Carbazol-1-yl)phenyl]-acetamide
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| Size/SKU | Availability | Price |
|---|---|---|
25 mg | Please contact Customer Service for Availability | 7 190,00 CZK |
About This Item
Empirical Formula (Hill Notation):
C20H16N2O
CAS Number:
Molecular Weight:
300.35
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
off-white to brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
CC(NC1=CC=CC=C1C2=CC=CC3=C2NC4=CC=CC=C43)=O
InChI key
LDPDVNYCIOHPGF-UHFFFAOYSA-N
Biochem/physiol Actions
GeA-69 is a selective allosteric inhibitor of macrodomain 2 of poly-adenosine-diphosphate-ribose polymerase 14 (PARP14), an anti-apoptotic pro-survival protein associated with inflammatory diseases and several types of cancer. GeA-69 exhibited a KD of 860 nM in ITC experiments. GeA-69 was shown to be an allosteric inhibitor of adenosine diphosphate ribose (ADPR) binding to PARP14 macrodomain 2 and to prevent recruitment of the PAPP14 macrodomain 2 to DNA damage sites.
Selective allosteric inhibitor of PARP14 macrodomain 2
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC) | description targeting mouse Parp14 | description - |
| form powder | form lyophilized powder | form solid |
| assay ≥98% (HPLC) | assay - | assay - |
| storage temp. 2-8°C | storage temp. −20°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility - | solubility - |
| color off-white to brown | color - | color - |
![2-Oxa-6-azaspiro[3.5]nonane](/deepweb/assets/sigmaaldrich/product/structures/175/594/1d536533-be27-4c08-8b88-105f2863ff4f/640/1d536533-be27-4c08-8b88-105f2863ff4f.png)
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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