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SML2296

GSK180736A

≥98% (HPLC)

Synonym(s):

4-(4-Fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-5-pyrimidinecarboxamide, GSK 180736A

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
7 350,00 CZK
6 247,50 CZK

About This Item

Empirical Formula (Hill Notation):
C19H16FN5O2
CAS Number:
Molecular Weight:
365.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

6 247,50 CZK

List Price7 350,00 CZKSave 15%
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assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(NC1=CC=C(NN=C2)C2=C1)C3=C(C)NC(NC3C4=CC=C(F)C=C4)=O

InChI

1S/C19H16FN5O2/c1-10-16(17(24-19(27)22-10)11-2-4-13(20)5-3-11)18(26)23-14-6-7-15-12(8-14)9-21-25-15/h2-9,17H,1H3,(H,21,25)(H,23,26)(H2,22,24,27)

InChI key

HEAIGWIZTYAQTC-UHFFFAOYSA-N

Biochem/physiol Actions

GSK180736A is a potent and selective dual inhibitor of a ROCK1 (Rho-associated, coiled-coil-containing protein kinase) and GRK2 (G protein-coupled receptor kinase 2). GSK180736A binds to the GRK2 active site. GSK180736A produces a significant cardiomyocytes contraction at 1 μM.
potent and selective dual inhibitor of a ROCK1 and GRK2


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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