SML3373

BZ194

≥98% (HPLC)

• Synonym(s): 3-Carboxy-1-[2-(octylamino)-2-oxoethyl]pyridinium bromide, 3-Carboxy-1-octylcarbamoylmethyl-pyridinium bromide, BZ 194, BZ-194
• Empirical Formula (Hill Notation): C₁₆H₂₅BrN₂O₃
• CAS Number: 936356-28-4
• Molecular Weight: 373.29
• UNSPSC Code: 12352200
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C(C[N+]1=CC(C(O)=O)=CC=C1)NCCCCCCCC.[Br-]
• InChI: 1S/C16H24N2O3.BrH/c1-2-3-4-5-6-7-10-17-15(19)13-18-11-8-9-14(12-18)16(20)21;/h8-9,11-12H,2-7,10,13H2,1H3,(H-,17,19,20,21);1H
• InChI key: LCFXDNPKEWPCGN-UHFFFAOYSA-N

Description

Biochem/physiol Actions

BZ194 is a selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to type 1 ryanodine receptor (RYR-1; IC50 ~10 uM against 1 uM NAADP). BZ194 inhibits Ca(2+) mobilization induced by NAADP (IC50 ~3 uM co-injected with 100 nM NAADP into Jurkat T cells), but not Ins(1,4,5)P3 or cyclic ADP-ribose (cADPR), and exhibits no inhibitory potency against capacitative Ca(2+) entry.

Selective nicotinic acid-adenine dinucleotide phosphate (NAADP) antagonist that blocks NAADP-stimulated ryanodine binding to RYR-1 and calcium mobilization.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable