SML4136

BB2-50F

≥98% (HPLC)

• Synonym(s): 3-Amino-N-(aminoiminomethyl)-6-(2-benzofuranyl)-5-(hexahydro-1H-azepin-1-yl)-2-pyrazinecarboxamide, 3-Amino-5-(azepan-1-yl)-6-(benzofuran-2-yl)-N-carbamimidoylpyrazine-2-carboxamide
• Empirical Formula (Hill Notation): C₂₀H₂₃N₇O₂
• CAS Number: 2226086-65-1
• Molecular Weight: 393.44
• NACRES: NA.21
• UNSPSC Code: 12352203
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: NC(NC(C1=NC(C2=CC(C=CC=C3)=C3O2)=C(N4CCCCCC4)N=C1N)=O)=N

Description

Biochem/physiol Actions

Cell penetrant, selective and potent multi-targeting bioenergetic inhibitor of succinate dehydrogenase and the F1Fo-ATP synthase in Mycobacterium tuberculosis; bactericidal antibiotic in MTB.
BB2-50F, an amiloride derivative, is a cell penetrant, selective and potent multi-targeting bioenergetic inhibitor of succinate dehydrogenase and the F1Fo-ATP synthase in Mycobacterium tuberculosis. BB2-50F act as fast acting bactericidal antibiotic in both replicating and nonreplicating cultures of M. tuberculosis (MIC = 2.6 µM in M. tuberculosis mc2 6230). BB2-50F is a potent inhibitor of bacterial motility.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable