SML4352

PVP-037

≥95% (HPLC)

• Synonym(s): α-Ethyl-N-(5-imidazo[1,2-a]pyrimidin-2-yl-2-methylphenyl)benzeneacetamide
• Empirical Formula (Hill Notation): C₂₃H₂₂N₄O
• CAS Number: 862810-50-2
• Molecular Weight: 370.45
• MDL number: MFCD05897784
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear (warmed)
• storage temp.: 2-8°C

Description

Biochem/physiol Actions

PVP-037 is a novel imidazopyrimidine (IMP) scaffold and a TLR7/8 agonist, demonstrating broad innate immune activation in primary human leukocytes at concentrations ≥1 µM, including NF-κB activation and Th1-polarizing cytokine production, notably TNF, IFN-γ and IL-1β comparable to R848 at concentrations ≥ 11 µM; it exhibits limited activity in THP-1 cells and murine/porcine primary leukocytes. In vivo, PVP-037, administered via intramuscular injection, enhances influenza and SARS-CoV-2 antigen-specific humoral responses in mice at 100 nmol doses and increases antibody titers co-administered with recombinant hemagglutinin (rHA) protein, compared to rHA alone or with alum, notably inducing a higher IgG response when formulated with rHA + PVP-037.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable