SML4444

(-)-Dehydrocostus lactone

≥98% (HPLC)

• Synonym(s): (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one, 6α-hydroxy-guaia-4(15),10(14),11(13)-trien-12-oic acid γ-lactone, Dehydro-costus lactone, Dehydrocostus lactone, Dehydrocostuslactone, Epiligulyl oxide, [3aS-(3aalpha,6aalpha,9aalpha,9bbeta)]-Decahydro-3,6,9-tris(methylene)-azuleno[4,5-b]furan-2(3H)-one
• Empirical Formula (Hill Notation): C₁₅H₁₈O₂
• CAS Number: 477-43-0
• Molecular Weight: 230.30
• UNSPSC Code: 12352200
• eCl@ss: 32160703
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C

Description

Biochem/physiol Actions

Suppressors of cytokine signaling (SOCS) proteins negatively regulate cytokine receptor signaling. The SOCS family include eight members SOCS-1 to SOCS-7 and CIS. Dehydrocostus lactone (DHE) is a sesquiterpene lactone extracted from Saussurea lappa and Aucklandia lappa. The compound possesses antifungal and antimycobacterial activity and exhibit a cytotoxic effect against HepG2, OVCAR-3, and HeLa cell lines. DHE inhibits cell proliferation not only in early-stage breast cancer MCF-7 but also in more advanced stage MDA-MB-231 cancer cells, without significant effect on H184B5F5/M10 normal mammary epithelial cells. The inhibition of breast cancer cells proliferation occurs through cell cycle blockade and apoptosis. DHE inhibits cell cycle progression and cell death through SOCS-1 and SOCS-3. Dehydrocostus lactone forms a chemical-synthetic lethal combination with subinhibitory doses of a FolE2 inhibitor trimethoprim in pathogen Burkholderia pseudomalle without annihilating the gut′s essential bacteria.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H317
• Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable