UC168

(±)-Bufuralol hydrochloride

≥98% (HPLC), solid, β-Adrenoceptor agonist/antagonist

• Synonym(s): α-[(tert-Butylamino)methyl]-7-ethyl-2-benzofuranmethanol hydrochloride
• Empirical Formula (Hill Notation): C₁₆H₂₃NO₂·HCl
• CAS Number: 60398-91-6
• Molecular Weight: 297.82
• NACRES: NA.77
• PubChem Substance ID: 24724644
• UNSPSC Code: 12161501
• EC Number: 262-216-3
• MDL number: MFCD00272648
• Form: solid

Properties

• Product Name: (±)-Bufuralol hydrochloride,
• form: solid
• Quality Segment: 200
• color: white to off-white
• mp: 143-146 °C
• solubility: H₂O: soluble, methanol: soluble
• storage temp.: 2-8°C
• SMILES string: Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C
• InChI: 1S/C16H23NO2.ClH/c1-5-11-7-6-8-12-9-14(19-15(11)12)13(18)10-17-16(2,3)4;/h6-9,13,17-18H,5,10H2,1-4H3;1H
• InChI key: KJBONRGCLLBWCJ-UHFFFAOYSA-N

Description

Application

CYP2D6 substrate

Biochem/physiol Actions

β-Blocker. Varying β-adrenoceptor agonist/antagonist activity.

Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

(±)-Bufuralol hydrochloride is soluble in water and methanol.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves