Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

ABSTRACT

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATERIALS

Product Number

Brand

Product Description

510033

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

510041

Sigma-Aldrich

Raney^®-Nickel, W.R. Grace and Co. Raney^® 4200, slurry, in H₂O, active catalyst

GF88419695

Nickel, insulated wire, 50m, conductor diameter 0.025mm, insulation thickness 0.0035mm, polyimide insulation

268259

Sigma-Aldrich

Nickel, foil, thickness 0.125 mm, ≥99.9%

GF93039633

Nickel, wire reel, 200m, diameter 0.125mm, annealed, 99.98%

267007

Sigma-Aldrich

Nickel, foil, thickness 0.25 mm, 99.995% trace metals basis

GF94031658

Nickel, foil, light tested, 25x25mm, thickness 0.015mm, 99.9%

GF30288539

Nickel, wire reel, 50m, diameter 1.0mm, as drawn, 99%

GF45193697

Nickel, rod, 100mm, diameter 2.0mm, annealed, 99%

GF17660594

Nickel, wire reel, 1m, diameter 2.0mm, hard, 99.98%

GF90754241

Nickel, rod, 100mm, diameter 40mm, 99%

GF81996014

Nickel, pellets, 100g, max. size 10mm, 99.99+%

GF44632818

Nickel, foil, light tested, 100x100mm, thickness 0.015mm, 99.9%

767484

Sigma-Aldrich

Nickel, sputtering target, diam. × thickness 2.00 in. × 0.25 in., 99.95% trace metals basis

357634

Sigma-Aldrich

Nickel, wire, diam. 0.25 mm, ≥99.9%

GF21754100

Nickel, rod, 500mm, diameter 12.7mm, 99.98%

GF32802511

Nickel, foil, 25mm disks, thickness 0.05mm, as rolled, 99.98%

GF51944665

Nickel, rod, 200mm, diameter 3.0mm, 99%

GF09893302

Nickel, tube, 1000mm, outside diameter 2.4mm, inside diameter 2.248mm, wall thickness 0.076mm, hard, 99.5%

GF25814077

Nickel, foil, 15mm disks, thickness 0.125mm, annealed, 99%

GF61221989

Nickel, foil, 4mm disks, thickness 0.5mm, as rolled, 100%

GF01381407

Nickel, tube, 100mm, outside diameter 1.8mm, inside diameter 1.6mm, wall thickness 0.1mm, hard, 99.5%

GF36396973

Nickel, foil, 15mm disks, thickness 0.075mm, as rolled, 99.98%

GF34230800

Nickel, rod, 500mm, diameter 3.0mm, 99%

GF66976116

Nickel, tube, 200mm, outside diameter 0.35mm, inside diameter 0.3mm, wall thickness 0.025mm, hard, 99.5%

GF95115731

Nickel, foil, 50mm disks, thickness 0.0075mm, 99.95%

GF44385903

Nickel, rod, 500mm, diameter 1.5mm, 99.99+%

GF20561385

Nickel, rod, 100mm, diameter 5.0mm, 99.99+%

GF03088627

Nickel, foil, 50mm disks, thickness 0.05mm, as rolled, 99.98%

GF26171344

Nickel, tube, 100mm, outside diameter 1.57mm, inside diameter 0.63mm, wall thickness 0.47mm, hard, 99.5%