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Merck

Sugarcoating Polycomb repression.

Developmental cell (2014-12-10)
C Peter Verrijzer
PMID25490262
ABSTRACT

The addition of the monosaccharide O-GlcNAc is one of the most mysterious posttranslational modifications. In this issue of Developmental Cell, Gambetta and Müller (2014) show that O-GlcNAcylation of the Drosophila Polycomb group (PcG) protein Polyhomeotic (PH) is essential for homeotic gene silencing. O-GlcNAcylation counteracts nonproductive aggregation of PH, allowing transcriptional repression.

MATERIALS
Product Number
Brand
Product Description
PHR1432
Supelco
N-Acetylglucosamine, Pharmaceutical Secondary Standard; Certified Reference Material
A3286
Sigma-Aldrich
N-Acetyl-D-glucosamine, suitable for cell culture, BioReagent
A8625
Sigma-Aldrich
N-Acetyl-D-glucosamine, ≥99% (HPLC)
A4106
Sigma-Aldrich
N-Acetyl-D-glucosamine, ≥95% (HPLC)