- Paclitaxel Reduces Axonal Bclw to Initiate IP
Paclitaxel Reduces Axonal Bclw to Initiate IP
Neuron (2017-10-13)
Sarah E Pease-Raissi, Maria F Pazyra-Murphy, Yihang Li, Franziska Wachter, Yusuke Fukuda, Sara J Fenstermacher, Lauren A Barclay, Gregory H Bird, Loren D Walensky, Rosalind A Segal
PMID29024661
ABSTRACT
Chemotherapy-induced peripheral neuropathy (CIPN) is a debilitating side effect of many cancer treatments. The hallmark of CIPN is degeneration of long axons required for transmission of sensory information; axonal degeneration causes impaired tactile sensation and persistent pain. Currently the molecular mechanisms of CIPN are not understood, and there are no available treatments. Here we show that the chemotherapeutic agent paclitaxel triggers CIPN by altering IP
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
Tetramethylrhodamine ethyl ester perchlorate, suitable for fluorescence, ≥90% (HPCE)
Sigma-Aldrich
8-Aminonaphthalene-1,3,6-trisulfonic acid disodium salt, BioReagent, suitable for fluorescence, ≥90% (CE)