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Merck

M26305

N-Methylacetamide

≥99%

Synonym(s):

Acetylmethylamine

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About This Item

Linear Formula:
CH3CONHCH3
CAS Number:
Molecular Weight:
73.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
201-182-6
Beilstein/REAXYS Number:
1071255
MDL number:

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Product Name

N-Methylacetamide, ≥99%

InChI key

OHLUUHNLEMFGTQ-UHFFFAOYSA-N

InChI

1S/C3H7NO/c1-3(5)4-2/h1-2H3,(H,4,5)

SMILES string

CNC(C)=O

assay

≥99%

refractive index

n20/D 1.433 (lit.)

bp

204-206 °C (lit.)

mp

26-28 °C (lit.)

density

0.957 g/mL at 25 °C (lit.)

Quality Level

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1 of 4

This Item
239356D98807D46904
assay

≥99%

assay

99%

assay

99%

assay

99%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

mp

26-28 °C (lit.)

mp

−140 °C (lit.)

mp

23 °C (lit.)

mp

-

refractive index

n20/D 1.433 (lit.)

refractive index

n20/D 1.372 (lit.)

refractive index

n20/D 1.524 (lit.)

refractive index

n20/D 1.44 (lit.)

density

0.957 g/mL at 25 °C (lit.)

density

0.675 g/mL at 25 °C (lit.)

density

1.06 g/mL at 25 °C (lit.)

density

0.864 g/mL at 25 °C (lit.)

bp

204-206 °C (lit.)

bp

36-38 °C (lit.)

bp

296-300 °C (lit.)

bp

120 °C/15 mmHg (lit.)

Application

N-Methylacetamide can be used:
  • To synthesize N-methyl-N-(3-thienyl)acetamide by reacting with 3-bromothiophene in the presence of CuI catalyst and N,N′-dimethylethylenediamine.(1)
  • As a ligand to synthesize the zirconium(IV) complex, Zr(MeC(O)NMe)4 by reacting with tetrakis(dimethylamido)zirconium.(2)

pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

240.8 °F

flash_point_c

116 °C

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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Michael Harder et al.
ChemMedChem, 8(3), 397-404 (2013-01-29)
The less polar π-surface of protein amide groups is exposed in many receptor binding sites, either as part of the backbone or in Gln/Asn side chains. Using quantum chemical calculations and Protein Data Bank (PDB) searches on model systems, we
Aneta Buczek et al.
Journal of molecular modeling, 18(6), 2471-2478 (2011-10-22)
A linear correlation between harmonic and anharmonic frequencies of water calculated at B3LYP level of theory was observed with a number of basis sets. Similar relationships were found in both the gas phase and solution for several small molecules. The
Hangfei Chen et al.
Environmental science & technology, 51(20), 11710-11717 (2017-09-15)
Amides represent an important class of nitrogen-containing compounds in the atmosphere that can in theory interact with atmospheric acidic particles and contribute to secondary aerosol formation. In this study, uptake coefficients (γ) of six alkylamides (C
Arend G Dijkstra et al.
The journal of physical chemistry. B, 115(18), 5392-5401 (2011-01-07)
The amide vibrational modes play an important role in energy transport and relaxation in polypeptides and proteins and provide us with spectral markers for structure and structural dynamics of these macromolecules. Here, we present a detailed model to describe the
Adolfo Bastida et al.
The journal of physical chemistry. A, 114(43), 11450-11461 (2010-10-12)
Nonequilibrium molecular dynamics (MD) simulations and instantaneous normal mode (INMs) analyses are used to study the vibrational relaxation of the C-H stretching modes (ν(s)(CH₃)) of deuterated N-methylacetamide (NMAD) in aqueous (D2O) solution. The INMs are identified unequivocally in terms of

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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