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Merck

8.17058

Maleic acid

EMPROVE® ESSENTIAL, Ph. Eur., NF

Synonym(s):

cis-Butenedioic acid, Toxilic acid

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1 KG

€137.00

25 KG

€1,830.00

€137.00


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About This Item

Linear Formula:
HO2CCH=CHCO2H
CAS Number:
Molecular Weight:
116.07
Beilstein:
605762
MDL number:
UNSPSC Code:
12352106
EC Index Number:
203-742-5

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Agency

NF
Ph. Eur.

Quality Level

vapor pressure

<0.1 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

Assay

99.0-101.0% substance (anhydrous) basis

form

solid

potency

708 mg/kg LD50, oral (Rat)
1560 mg/kg LD50, skin (Rabbit)

technique(s)

API processing | cocrystal formation: suitable
API processing | salt formation: suitable

pH

1.3 (20 °C, 100 g/L in H2O)

mp

130-135 °C (lit.)

solubility

478.8 g/L

density

1.59 g/mL at 25 °C (lit.)

cation traces

Fe: ≤5 ppm
V: ≤1 ppm
heavy metals (as Pb): ≤10 ppm

application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

storage temp.

15-25°C

SMILES string

OC(=O)\C=C/C(O)=O

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1-

InChI key

VZCYOOQTPOCHFL-UPHRSURJSA-N

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1 of 4

This Item
92816MX01008.00380
application(s)

liquid formulation
pharmaceutical
semi-solid formulation
solid formulation

application(s)

cleaning products
cosmetics
flavors and fragrances
food and beverages
personal care
pharmaceutical

application(s)

-

application(s)

-

technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

technique(s)

gas chromatography (GC): suitable, qNMR: suitable

technique(s)

-

technique(s)

-

agency

NF, Ph. Eur.

agency

-

agency

-

agency

-

form

solid

form

-

form

crystalline powder

form

powder

assay

99.0-101.0% substance (anhydrous) basis

assay

-

assay

≥98%

assay

≥99% (acidimetric)

density

1.59 g/mL at 25 °C (lit.)

density

1.59 g/mL at 25 °C (lit.)

density

1.59 g/mL at 25 °C (lit.)

density

1.59 g/mL at 25 °C (lit.)

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Maleic acid is typically used as pH adjuster or buffer agent in pharmaceutical formulations. Maleic acid Emprove® Essential is mainly used in highly regulated pharmaceutical applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

CorrosionExclamation mark

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1


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