This antibody is supplied in the form of unpurified polyclonal rabbit serum, for which the exact specific antibody concentration is not determined. However, for polyclonal antiserum, the specific antibody concentrations could range from 1-10 mg/mL serum, but typically range from 1–3 mg/mL serum.
AB2201
Anti-mPER1 (residues 6-21) Antibody
serum, from rabbit
Synonym(s):
Circadian clock protein PERIOD 1, Circadian pacemaker protein Rigui, Period, drosophila, homolog of period 1, period (Drosophila) homolog 1, period homolog 1 (Drosophila)
Sign In to View Organizational & Contract Pricing
Select a Size
Pricing and availability is not currently available.
About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Skip To
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
technique(s)
western blot: suitable
GenBank accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
mouse ... Per1(18626)
1 of 4
This Item | SAB1400200 | WH0008864M1 | AB2202 |
|---|---|---|---|
| biological source rabbit | biological source mouse | biological source mouse | biological source rabbit |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| antibody form serum | antibody form IgG fraction of antiserum | antibody form purified immunoglobulin | antibody form serum |
| shipped in wet ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| technique(s) western blot: suitable | technique(s) indirect immunofluorescence: suitable, western blot: 1 μg/mL | technique(s) immunofluorescence: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, western blot: 1-5 μg/mL | technique(s) western blot: suitable |
General description
136 kDa
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
Application
Detect mPER1 (residues 6-21) using this Anti-mPER1 (residues 6-21) Antibody validated for use in WB.
Immunohistichemistry:
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Tested on whole brain (SCN; peak staining at CT/ZT12). Optimium working dilutions need to be determined by end used.
Biochem/physiol Actions
Cat. # AB2201 will recognize the N-terminus of mPER1.
May react with Drosophila, Arvicanthis niloticus and Mesocricetus auratus based on sequence homology. Reactivity with other species has not been tested.
Analysis Note
Routinely tested by western blot on human brain lysate
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Floriana Mogavero et al.
The European journal of neuroscience, 55(6), 1492-1503 (2022-03-02)
Although aggression has been linked to disturbances of circadian rhythm, insight into the neural substrate of this association is currently lacking. The suprachiasmatic nucleus (SCN) of the hypothalamus, the master circadian clock, is regulated by clock genes and known to
Nobuko Katoku-Kikyo et al.
PLoS biology, 21(12), e3002419-e3002419 (2023-12-04)
Circadian regulation of gene expression is prevalent and plays critical roles in cell differentiation. However, its roles in the reprogramming of differentiated cells remain largely unknown. Here, we found that one of the master circadian regulators PER1 promoted virus-mediated reprogramming
Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids.
Yasuhiro Umemura et al.
Proceedings of the National Academy of Sciences of the United States of America, 119(1) (2021-12-22)
In mammals, circadian clocks are strictly suppressed during early embryonic stages, as well as in pluripotent stem cells, by the lack of CLOCK/BMAL1-mediated circadian feedback loops. During ontogenesis, the innate circadian clocks emerge gradually at a late developmental stage, and
Wenhao Ge et al.
Journal of lipid research, 64(6), 100390-100390 (2023-05-21)
Several epidemiological studies suggest a correlation between eating time and obesity. Night eating syndrome characterized by a time-delayed eating pattern is positively associated with obesity in humans as well as in experimental animals. Here, we show that oil intake at
Hao Lin et al.
Clocks & sleep, 5(4), 639-650 (2023-11-21)
The circadian clock regulates a variety of biological processes that are normally synchronized with the solar day. Disruption of circadian rhythms is associated with health problems. Understanding the signaling mechanisms that couple cell physiology and metabolism to circadian timekeeping will
Related Content
-
What is the concentration ?
1 answer-
Helpful?
-
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service