Poloxamer 407, micronized

Name: Poloxamer 407, micronized
Brand: SIGMA

Synonym(s):

Poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Lμtrol micro 127

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About This Item

CAS Number:

9003-11-6

UNSPSC Code:

12161900

NACRES:

NA.25

MDL number:

MFCD00082049

Key Documents

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SMILES string

O2C(C2)C.O1CC1

InChI

1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2

InChI key

RVGRUAULSDPKGF-UHFFFAOYSA-N

mol wt

~9840-14600 g/mol

composition

oxyethylene content, 71.5-74.9%

impurities

≤0.25% ethylene glycol and diethylene glycol
≤0.4% total ash
≤0.75% water
≤1 ppm ethylene oxide
≤2 ppm arsenic
≤20 ppm heavy metals
50-125 ppm butylhydroxytoluene

ign. residue

≤0.30%

color

APHA: ≤120

particle size distribution

, coeff var ≤10% (residue, No. 140 USS)
, coeff var ≤50% (residue, No. 270 USS)

pH

5.0-7.5(1:10)
5.0-7.5(1:40)

suitability

complies for Infrared spectrum

Quality Level

100

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Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

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Show Differences

1 of 4

This Item	78973	1.37112	K4894
Sigma-Aldrich 50246 Poloxamer 407, micronized	Sigma-Aldrich 78973 Poloxamer 188, micronized	SAFC 1.37112 Poloxamer 188	Sigma-Aldrich K4894 Poloxamer 188
suitability complies for Infrared spectrum	suitability complies for Infrared spectrum	suitability -	suitability -
Quality Level 100	Quality Level 100	Quality Level 500	Quality Level 300
mol wt ~9840-14600 g/mol	mol wt ~7680-9510 g/mol	mol wt -	mol wt 8.400 g/mol
impurities ≤0.25% ethylene glycol and diethylene glycol, ≤0.75% water, ≤2 ppm arsenic, 50-125 ppm butylhydroxytoluene, ≤0.4% total ash, ≤20 ppm heavy metals, ≤1 ppm ethylene oxide	impurities organic volatile impurities, complies (meets USP requirements), ≤0.4% total ash, ≤0.75% water, ≤1 ppm ethylene oxide, ≤20 ppm heavy metals, ≤5 ppm 1,4-dioxane, ≤5 ppm propylene oxide, 50-125 ppm butylhydroxytoluene	impurities -	impurities -
composition oxyethylene content, 71.5-74.9%	composition oxyethylene content, 79.9-83.7%	composition -	composition -
ign. residue ≤0.30%	ign. residue -	ign. residue -	ign. residue -

Legal Information

Pluronic is a registered trademark of BASF

Analysis Note

residual solvents (GLC-HS)
1,4-dioxane ≤5 ppm, ethylene glycol ≤620 ppm ( verified on random samples only)

Application

The Poloxamer 407 grades are poloxamers from the extensive line of Pluronic^® block copolymers. They are widely used as a thickening agent and gel binder.

Other Notes

average molecular weight/mass 9840-14600 g/mol; average molecular mass 10000-14600 g/mol

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Preparation and evaluation of folate-modified cationic pluronic micelles for poorly soluble anticancer drug.

Wei Xu et al.

Drug delivery, 19(4), 208-219 (2012-05-31)

The aim of this study was to construct novel targeting polymeric micelles. Folate-Poly (ethylenimine)-Pluronic copolymers were synthesized. A paclitaxel (PTX)-loaded mixed micelles consisting of Folate-Poly (ethylenimine)-Pluronic and Pluronic L121 copolymers have been developed. The mixed micelles showed nano-sized spherical morphology.

Reversible controlled assembly of thermosensitive polymer-coated gold nanoparticles.

Céline Durand-Gasselin et al.

Langmuir : the ACS journal of surfaces and colloids, 27(20), 12329-12335 (2011-09-29)

Aggregation of thermosensitive polymer-coated gold nanoparticles was performed in aqueous solution in the presence of a triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic P123, PEO(20)-PPO(68)-PEO(20)). The gold nanoparticles, AuNPs, which are covered by thermosensitive statistical copolymers poly(EO(x)-st-PO(y)), aggregate when the

Curcumin loaded mixed micelles composed of Pluronic P123 and F68: preparation, optimization and in vitro characterization.

Liyan Zhao et al.

Colloids and surfaces. B, Biointerfaces, 97, 101-108 (2012-05-23)

In this study, curcumin (Cur) loaded mixed micelles (Cur-PF), composed of Pluronic P123 (P123) and Pluronic F68 (F68), was prepared using the thin-film hydration method and evaluated in vitro. The preparation process was optimized with a central composite design (CCD).

Structural characterization and antimicrobial properties of silver nanoparticles prepared by inverse microemulsion method.

Irshad A Wani et al.

Colloids and surfaces. B, Biointerfaces, 101, 243-250 (2012-09-27)

Silver nanoparticles have been synthesized in the inverse microemulsions formed using three different surfactants viz., cetyl-trimethyl ammonium bromide (CTAB), Tergitol and Triton X-100. We have done a systematic study of the effect of the surfactants on the particle size and

Chylomicron formation and secretion is required for lipid-stimulated release of incretins GLP-1 and GIP.

Wendell J Lu et al.

Lipids, 47(6), 571-580 (2012-02-03)

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are incretins produced in the intestine that play a central role in glucose metabolism and insulin secretion. Circulating concentrations of GLP-1 and GIP are low and can be difficult to assay in

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