No, this product is not intended for used as an analytical standard. The material has not been tested against any compendial or agency standard.
80198
Methoxatin disodium salt
≥97.0% (HPLC)
Synonym(s):
PQQ, Pyrrolo-quinoline-quinone disodium salt
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About This Item
Empirical Formula (Hill Notation):
C14H4N2Na2O8
CAS Number:
Molecular Weight:
374.17
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352005
MDL number:
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Product Name
Methoxatin disodium salt, ≥97.0% (HPLC)
InChI key
UFVBOGYDCJNLPM-UHFFFAOYSA-L
SMILES string
OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]
InChI
1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2
biological source
fermentation/recombinant
assay
≥97.0% (HPLC)
form
powder
color
red-brown to deep orange
red-brown to deep red-brown
storage temp.
2-8°C
Quality Level
Related Categories
1 of 4
This Item | D7783 | N183 | D8284 |
|---|---|---|---|
| assay ≥97.0% (HPLC) | assay ≥95.0% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| biological source fermentation/recombinant | biological source synthetic | biological source - | biological source - |
| form powder | form powder | form lyophilized powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 200 |
| color red-brown to deep orange | color red to deep red | color , brown to dark red-brown | color white to light yellow |
Application
- Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ): This study investigates the safety profile of Methoxatin disodium salt, which has implications for its application in assay development for clinical and diagnostic purposes. Specifically, it addresses the compound′s use in dietary supplements and potential crossover into clinical assays where safety and toxicity are paramount (Shiojima et al., 2022).
Biochem/physiol Actions
In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor.[1] It acts as a cofactor[1] (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers.[2] In bovine plasma amine oxidase, methoxatin may acts as the cofactor.[3]
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Pyrroloquinoline Quinone: Its Profile, Effects on the Liver and Implications for Health and Disease Prevention
Dietary Interventions in Liver Disease, 157-173 (2019)
Lingbo Kong et al.
PloS one, 8(4), e61013-e61013 (2013-04-25)
The effects of pyrroloquinoline quinine (PQQ) on RANKL-induced osteoclast differentiation and on wear particle-induced osteolysis were examined in this study. PQQ inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of cytotoxicity. The
Mohamed Alburaki et al.
PloS one, 10(5), e0125790-e0125790 (2015-05-21)
Thirty-two honeybee (Apis mellifera) colonies were studied in order to detect and measure potential in vivo effects of neonicotinoid pesticides used in cornfields (Zea mays spp) on honeybee health. Honeybee colonies were randomly split on four different agricultural cornfield areas
Peilian Wei et al.
Preparative biochemistry & biotechnology, 47(7), 709-719 (2017-04-28)
Methylobacillus sp. zju323 was adopted to improve the biosynthesis of pyrroloquinoline quinone (PQQ) by systematic optimization of the fermentation medium. The Plackett-Burman design was implemented to screen for the key medium components for the PQQ production. CoCl
Gerasimos F Kremmydas et al.
PloS one, 8(4), e61808-e61808 (2013-04-19)
Pseudomonas fluorescens strain X, a bacterial isolate from the rhizosphere of bean seedlings, has the ability to suppress damping-off caused by the oomycete Pythium ultimum. To determine the genes controlling the biocontrol activity of strain X, transposon mutagenesis, sequencing and
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Can this be used as a Certified Standard or Secondary Standard?
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What solvents can be used to reconstitute Product 80198, Methoxatin?
1 answer-
Product 80198, Methoxatin disodium salt is soluble in water up to 3 mg/ml. The following reference by Zimmerman, L.B. et al., Analytical Biochemistry, 411 (2), 194-199 (2011) has solubilized the product in 250 μM in HEPES buffer (20 mM, pH 7.0, 290 mOsmol/kg).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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