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Merck

A5971

Anti-Water Channel Aquaporin 4 antibody produced in rabbit

lyophilized powder, affinity isolated antibody

Synonym(s):

Anti-AQP4, Anti-Mercurial-Insensitive Water Channel, Anti-WCH4

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:

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Product Name

Anti-Water Channel Aquaporin 4 antibody produced in rabbit, lyophilized powder, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human, mouse, rat

technique(s)

flow cytometry: suitable (indirect)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

UniProt accession no.

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

Gene Information

human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)

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This Item
ABN910HPA014784AB2218
Quality Level

200

Quality Level

-

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

conjugate

-

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

UniProt accession no.

P55087

UniProt accession no.

P47863

UniProt accession no.

P55087

UniProt accession no.

P55087

Gene Information

human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)

Gene Information

human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)

Gene Information

human ... AQP4(361)

Gene Information

human ... AQP4(361)

Application

Rabbit Anti-Water Channel Aquaporin 4 antibody can be used for immunohistochemical applications. The antibody can also be used for immunocytochemistry, western blot and flow cytometry applications.

Biochem/physiol Actions

Immunoprecipation and western blot analysis using HEK-293 cells that had been transfected with GFP-AQP4 was performed using rabbit anti-AQP4 as the primary antibody at 2μl/ml.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

AQP4 is an osmoreceptor that regulates water flow in the CNS. It is abundant in astrocytes, but is also weakly noticeable in pulmonary, intestinal, ocular and renal tissues. Rabbit Anti-Water Channel Aquaporin 4 antibody recognizes aquaporin 4 in human, mice and rats.

Immunogen

recombinant fusion protein corresponding to residues 249-323 of rat AQP4 fused to GST.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Krysti L Todd et al.
Frontiers in aging neuroscience, 9, 445-445 (2018-01-31)
Ventriculomegaly (expansion of the brain's fluid-filled ventricles), a condition commonly found in the aging brain, results in areas of gliosis where the ependymal cells are replaced with dense astrocytic patches. Loss of ependymal cells would compromise trans-ependymal bulk flow mechanisms
Friederike Tuller et al.
Journal of neuroinflammation, 13(1), 176-176 (2016-07-03)
The discovery of a highly specific antibody against the aquaporin-4 (AQP4) water channel (AQP4-IgG) unified the spectrum of neuromyelitis optica spectrum disorders (NMOSD), which are considered to be antibody-mediated autoimmune diseases. The AQP4 water channel is located on astrocytic end-feet
Michelle Figueroa et al.
JAMA neurology, 71(4), 495-498 (2014-04-16)
Reports of neuromyelitis optica spectrum disorder (NMOSD) occurring in the setting of neoplasia suggest that aquaporin-4 autoimmunity may in some cases have a paraneoplastic basis. In this case report, we describe a patient with NMOSD whose test results were seropositive
Paraneoplastic Neuromyelitis Optica Associated with Lung Adenocarcinoma in a Young Woman.
Kyoung Won Baik et al.
Journal of clinical neurology (Seoul, Korea), 14(2), 246-247 (2018-04-10)
Gry Fluge Vindedal et al.
Molecular and cellular neurosciences, 77, 47-52 (2016-11-05)
There is a constitutive production of water in brain. The efflux routes of this excess water remain to be identified. We used basal brain water content as a proxy for the capacity of water exit routes. Basal brain water content

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