Used as standard for TLC, worked OK, stainned less than other lipids with iodine, but that may be be normal
C8667
Cholesterol
Cholesterol
1 of 1 reviewers received a sample product or took part in a promotion
Sigma Grade, ≥99%
Synonym(s):
3β-Hydroxy-5-cholestene, 5-Cholesten-3β-ol
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500 MG
€44.20
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€45.00
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€77.10
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€399.00
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500 MG
€44.20
1 G
€45.00
5 G
€77.10
25 G
€399.00
100 G
€1,360.00
About This Item
Empirical Formula (Hill Notation):
C27H46O
CAS Number:
Molecular Weight:
386.65
Beilstein:
1915888
EC Number:
MDL number:
UNSPSC Code:
12352111
eCl@ss:
39023139
PubChem Substance ID:
NACRES:
NA.77
biological source
sheep wool
Quality Level
grade
Sigma Grade
Assay
≥99%
form
powder
bp
360 °C (lit.)
mp
147-149 °C (lit.)
solubility
water: soluble 0.00003 g/L at 20 °C
density
1.067 g/mL at 25 °C (lit.)
shipped in
ambient
storage temp.
−20°C
SMILES string
CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
InChI
1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key
HVYWMOMLDIMFJA-DPAQBDIFSA-N
Gene Information
human ... POLA1(5422), TOP2A(7153)
rat ... Ar(24208), Polb(29240)
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Related Categories
1 of 4
This Item | 228111 | 700100P | 700000P |
|---|---|---|---|
| assay ≥99% | assay ≥90% (HPLC) | assay >99% (TLC) | assay >98% (TLC) |
| biological source sheep wool | biological source - | biological source - | biological source - |
| grade Sigma Grade | grade - | grade - | grade - |
| storage temp. −20°C | storage temp. 10-30°C | storage temp. −20°C | storage temp. −20°C |
| form powder | form powder | form powder | form powder |
| shipped in ambient | shipped in ambient | shipped in dry ice | shipped in dry ice |
Application
Cholesterol was used to prepare immune-stimulating complexes to enhance cellular and humoral responses.[1] It was incorporated in animal feed to study the effect of cholesterol-rich diet.[2][3]
Standard for chromatography
Biochem/physiol Actions
Cholesterol is a lipid that makes up about 20-25% of the structural components of the cell membranes. It determines the fluidity and permeability of the membrane, making it permeable to water but not to ions and protons. Cholesterol also regulates the functions of the transporters and signaling proteins present on the plasma membrane.[4] The major sites of cholesterol synthesis are small intestine and liver.[5]
Major component of all biological membranes; ~25% of total brain lipid is cholesterol.
Preparation Note
Cholesterol monohydrate yields a clear, colorless to faint yellow solution in hot alcohol. It is also soluble in acetone, dioxane, ethyl acetate, benzene, petroleum ether, oils, fats, and in aqueous solutions of bile salts. Solutions should be protected from light.
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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