N4288

Anti-NAV3 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Neuron navigator 3, Anti-Pore membrane and/or filament interacting like protein 1 (POMFIL1), Anti-STEERIN3, Anti-human UNC-53 homolog (unc53H3)
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~280 kDa
• species reactivity: human, mouse (predicted), rat (predicted)
• packaging: antibody small pack of 25 μL
• enhanced validation: recombinant expression; Learn more about Antibody Enhanced Validation
• concentration: ~1 mg/mL
• technique(s): western blot: 1-2 μg/mL using HEK-292T cells lysate expressing human NAV3 fusion protein
• UniProt accession no.: Q8IVL0
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... NAV3(89795) ; mouse ... Nav3(260315) ; rat ... Nav3(314814)

Description

General description

NAV3 belongs to the neuron navigator (NAV) family of proteins. NAV3 is expressed in adult heart, kidney, and brain.

Neuron navigator 3 (NAV3) is highly expressed in tumors. It possesses actin-binding domains and the gene encoding it is localized on chromosome 12q21.

Application

Anti-NAV3 (C-terminal) antibody has been used in immunoblotting, western blotting.

Biochem/physiol Actions

NAV3 has been suggested to function as a novel tumor suppressor gene. Deletions and translocation affecting NAV3 have been shown to occur in patients with advanced mycosis fungoides or Sézary syndrome, the most common forms of primary cutaneous T-cell lymphoma (CTCL).

Neuron navigator 3 (NAV3) has been shown to control migration and invasion of epithelial cells. Once it is activated by growth factors, NAV3 occupies the ends of microtubules and stimulates their growth.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves