R1512

Retinyl palmitate

potency: ≥1,700,000 USP units per g

• Synonym(s): Vitamin A palmitate, all−trans−Retinol palmitate
• Empirical Formula (Hill Notation): C₃₆H₆₀O₂
• CAS Number: 79-81-2
• Molecular Weight: 524.86
• UNSPSC Code: 12352205
• NACRES: NA.79
• PubChem Substance ID: 24899347
• EC Number: 201-228-5
• Beilstein/REAXYS Number: 1917366
• MDL number: MFCD00019414

Properties

• Product Name: Retinyl palmitate, potency: ≥1,700,000 USP units per g
• InChI key: VYGQUTWHTHXGQB-FFHKNEKCSA-N
• InChI: 1S/C36H60O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-25-35(37)38-30-28-32(3)23-20-22-31(2)26-27-34-33(4)24-21-29-36(34,5)6/h20,22-23,26-28H,7-19,21,24-25,29-30H2,1-6H3/b23-20+,27-26+,31-22+,32-28+
• SMILES string: CC1=C(/C=C/C(C)=C/C=C/C(C)=C/COC(CCCCCCCCCCCCCCC)=O)C(C)(C)CCC1
• biological source: synthetic (organic)
• form: solid or viscous liquid
• potency: ≥1,700,000 USP units per g
• does not contain: antioxidant
• color: yellow to yellow-green
• mp: 26 °C
• storage temp.: 2-8°C
• Quality Level: 200

Description

Application

Retinyl palmitate has been used as a standard in high performance liquid chromatography (HPLC).[1] It has also been used to study its effect on brain regeneration in larval Xenopus laevis.[2]

Biochem/physiol Actions

Retinyl palmitate is widely used in pharmaceutical applications.[3] It is also extensively used in cosmetic formulations due to its beneficial effects on the appearance of skin and anti-oxidant properties.[4] Retinyl palmitate acts as a teratogen and affect vertebrate embryogenesis and regeneration.[2] It is added as a source of vitamin A in low fat and skim milks.[5] Retinyl palmitate acts as a chemopreventive or antineoplastic agent.[6]

Review: Vitamin A metabolism.

General description

Retinyl palmitate or vitamin A palmitate is a retinoid,[2] which is an acid form of vitamin A. Retinoids exist as many geometric isomers due to the unsaturated bonds in the aliphatic chain. Retinyl palmitate is a major storage form of vitamin A found in epidermis.[3] Retinyl esters provide pools of vitamin A that are converted into retinol and other retinoids as needed.[7]

Packaging

Sealed ampule.

Physical form

oil or solid

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H360D,H412
• pcodes: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Aquatic Chronic 3 - Repr. 1B
• Storage Class: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 2
• flash_point_f: No data available
• flash_point_c: No data available
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter