SAB4300448

Anti-FLT3 (Ab-591) antibody produced in rabbit

affinity isolated antibody

• Synonym(s): Anti-CD135 antibody produced in rabbit, Anti-FLK2 antibody produced in rabbit, Anti-STK1 antibody produced in rabbit, Anti-fms-related tyrosine kinase 3 antibody produced in rabbit
• MDL number: MFCD01633120
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: ~130 kDa; ~160 kDa
• species reactivity: human
• concentration: 1 mg/mL
• technique(s): indirect immunofluorescence: 1:100-1:200
• isotype: IgG
• immunogen sequence: (Y-F-Y-V-D)
• NCBI accession no.: NP_004110.2
• UniProt accession no.: P36888
• shipped in: wet ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FLT3(2322)

Description

General description

FLT3 encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Immunogen

Peptide sequence around aa. 589-593 (Y-F-Y-V-D), according to the protein FLT3.

Features and Benefits

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Physical form

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable