SML0327

AM630

≥90% (HPLC), CP 55,940 antagonist, powder

• Synonym(s): 6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4-methoxyphenyl)methanone, AM 630, Iodopravadoline
• Empirical Formula (Hill Notation): C₂₃H₂₅IN₂O₃
• CAS Number: 164178-33-0
• Molecular Weight: 504.36
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825332
• NACRES: NA.77
• MDL number: MFCD01861183

Properties

• Product Name: AM630, ≥90% (HPLC)
• SMILES string: COc1ccc(cc1)C(=O)c2c(C)n(CCN3CCOCC3)c4cc(I)ccc24
• InChI: 1S/C23H25IN2O3/c1-16-22(23(27)17-3-6-19(28-2)7-4-17)20-8-5-18(24)15-21(20)26(16)10-9-25-11-13-29-14-12-25/h3-8,15H,9-14H2,1-2H3
• InChI key: JHOTYHDSLIUKCJ-UHFFFAOYSA-N
• assay: ≥90% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: >5 mg/mL
• storage temp.: 2-8°C
• Quality Level: 100

Description

Application

AM630 has been used:

• as a cannabinoid 2(CB2) inhibitor to study the analgesic effect exerted by polysaccharopeptide from Trametes versicolor (TPSP).[1]
• as a CB2 antagonist along with β-caryophyllene (BCP) to study its effects on re-epithilialization of fibroblast cells.[2]
• as a CB2 antagonist to study its interaction with 17-β-estradiol in primary human osteoblasts.[3]

Biochem/physiol Actions

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist (Ki = 31.2 nM) with > 150-fold selectivity over CB1 receptors.

AM630 is a selective CB2 cannabinoid antagonist/inverse agonist.

AM630 is an aminoalkylindole and acts as a competitive antagonist of CP 55,940 and WIN 55,212-2. It also behaves as a competitive antagonist of anandamide and (R)-(+)-arachidonyl-1′-hydroxy-2′-propylamide (AM356).[4]

Features and Benefits

This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• pictograms: GHS09
• signalword: Warning
• hcodes: H410
• pcodes: P273 - P391 - P501
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable