ABC99

Sigma-Aldrich

Anti-SFTPC Antibody

from rabbit, purified by affinity chromatography

Sinónimos:
Pulmonary surfactant-associated protein C, SP-C, Pulmonary surfactant-associated proteolipid SPL(Val), SP5
eCl@ss:
32160702
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100

antibody product type

primary antibodies

clon

polyclonal

purificado por

affinity chromatography

species reactivity

rat, human, mouse

aplicaciones

immunohistochemistry: suitable (paraffin)
western blot: suitable

Nº de acceso NCBI

Nº de acceso UniProt

enviado en

wet ice

Gene Information

human ... SFTPC(6440)

Descripción general

SFTPC, also known as SFTP2 and Pulmonary surfactant-associated protein C, is a complex mixture of phospholipids and proteins secreted from airway epithelial cells (type II cells) in alveoli which reduces the surface tension at the alveolar air liquid interface, providing alveolar stability necessary for normal ventilation. Four distinct proteins isolated from pulmonary surfactant are termed surfactant proteins A, B, C, and D. SP A (28 - 36 kDa) and SP D (43 kDa) are collagenous carbohydrate binding proteins, whereas SP B (8 - 9 kDa) and SP C (4 kDa) are non collagenous hydrophobic proteins. SP C is a fragment of a much larger precursor protein of 21 kDa. The precursor contains an exceedingly hydrophobic region of 34 amino acids that comprises most of the mature SP C, and a unique poly-valine domain.

Inmunógeno

KLH-conjugated linear peptide corresponding to the N-terminus of human SFTPC.
Epitope: N-terminus

Aplicación

Research Sub Category
Apoptosis - Additional
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected SFTPC in human lung tissue.
Detect SP-C using this rabbit polyclonal antibody, Anti-SFTPC Antibody validated for use in western blotting & IHC (Paraffin).
Research Category
Apoptosis & Cancer

Calidad

Evaluated by Western Blotting in rat lung tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected SFTPC in 10 µg of rat lung tissue lysate.

Descripción de destino

~20 kDa observed

Forma física

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity Purfied

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Nota de análisis

Control
Rat lung tissue lysate

Otras notas

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

WGK Alemania

WGK 1

Punto de inflamabilidad F

Not applicable

Punto de inflamabilidad C

Not applicable

William J Zacharias et al.
Nature, 555(7695), 251-255 (2018-03-01)
Functional tissue regeneration is required for the restoration of normal organ homeostasis after severe injury. Some organs, such as the intestine, harbour active stem cells throughout homeostasis and regeneration; more quiescent organs, such as the lung, often contain facultative progenitor...
null
Maria Plataki et al.
JCI insight, 5 (2019-07-10)
The prevalence of obesity is rising worldwide and obese patients comprise a specific population in the intensive care unit. Acute respiratory distress syndrome (ARDS) incidence is increased in obese patients. Exposure of rodents to hyperoxia mimics many of the features...
Kuei-Pin Chung et al.
Nature communications, 10(1), 3390-3390 (2019-07-31)
Accumulating evidence illustrates a fundamental role for mitochondria in lung alveolar type 2 epithelial cell (AEC2) dysfunction in the pathogenesis of idiopathic pulmonary fibrosis. However, the role of mitochondrial fusion in AEC2 function and lung fibrosis development remains unknown. Here...
Yulong Chen et al.
The Journal of clinical investigation, 125(3), 1147-1162 (2015-02-11)
Epithelial tumor metastasis is preceded by an accumulation of collagen cross-links that heighten stromal stiffness and stimulate the invasive properties of tumor cells. However, the biochemical nature of collagen cross-links in cancer is still unclear. Here, we postulated that epithelial...

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