A3940

1-Aminobenzotriazole

≥98% (TLC), powder, cytochrome P450 inhibitor

• Sinónimos: 1-Benzotriazolamine, ABT
• Fórmula lineal: H₂NC₆H₄N₃
• Número CAS: 1614-12-6
• Peso molecular: 134.14
• NACRES: NA.77
• PubChem Substance ID: 24278226
• UNSPSC Code: 12352200
• MDL number: MFCD00132902
• Beilstein/REAXYS Number: 607843
• eCl@ss: 32150313
• Assay: ≥98% (TLC)
• Form: powder

Propiedades

• Nombre del producto: 1-Aminobenzotriazole,
• Quality Segment: 200
• product category: bioactive small molecules
• assay: ≥98% (TLC)
• form: powder
• greener alternative product score: old score: 93; new score: 46; Find out more about DOZN™ Scoring
• sustainability: Sustainability features
• mp: 81-84 °C (lit.)
• solubility: ethanol: 49-51 mg/mL, clear, pale yellow to yellow
• SMILES string: Nn1nnc2ccccc12
• InChI: 1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
• InChI key: JCXKHYLLVKZPKE-UHFFFAOYSA-N
• Gene Information: human ... CYP1A2(1544)

Descripción

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives. This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Waste Prevention”, “Safer Solvents and Auxiliaries” and “Inherently Safer Chemistry for Accident Prevention”. Click here to view its DOZN scorecard.

Application

1-Aminobenzotriazole has been used as a cytochrome P450 inhibitor to study the effects of estrogen on H₂O₂-induced premature senescence of vascular smooth muscle cells from old rats It has also been used to study the estrogen receptor-mediated effects of 17β-estradiol.

Biochem/physiol Actions

Suicide inhibitor of cytochrome P450 and chloroperoxidase.

1-Aminobenzotriazole (1-ABT) is used as an in vitro tool in drug discovery. It can differentiate the P450 from non-P450 enzyme systems. 1-ABT exhibits inhibitory action by covalent alteration of the heme prosthetic group in the P450 enzyme.

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H315,H319,H335
• Indicaciones de precaución: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos diana: Respiratory system
• Clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable
• EPI (equipos de protección individual): dust mask type N95 (US), Eyeshields, Gloves