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C1801

Sigma-Aldrich

Monoclonal Anti-Cytokeratin, pan antibody produced in mouse

clone PCK-26, ascites fluid

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Sinónimos:
Monoclonal Anti-pan-Cytokeratin

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

PCK-26, monoclonal

contiene

15 mM sodium azide

reactividad de especies

human, chicken, snake, hamster, pig, goat, feline, bovine, carp, rat, rabbit, canine, lizard, sheep, mouse, guinea pig

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:300
immunohistochemistry (frozen sections): suitable
indirect immunofluorescence: 1:300 using protease-idgested, formalin-fixed, paraffin-embedded sections of human or animal tissues
western blot: suitable

isotipo

IgG1

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

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Este artículo
C2931C5992F3418
Gene Information

bovine ... Krt1(100301161)
dog ... Krt1(444857)
human ... KRT1(3848), KRT1(3848), KRT1(3848), KRT5(3852), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856), KRT8(3856)
mouse ... KRT1(16678), KRT1(16678), KRT1(16678), Krt1(16678), Krt5(110308), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691), Krt8(16691)
rat ... Krt1(300250), Krt2-5(369017), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626), Krt2-8(25626)

Gene Information

bovine ... Krt1(100301161)
human ... KRT1(3848), KRT13(3858), KRT13(3858), KRT18(3875), KRT18(3875), KRT4(3851), KRT4(3851), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856)
mouse ... Krt1(16678), Krt10(16661), Krt10(16661), Krt13(16663), Krt13(16663), Krt18(16668), Krt18(16668), Krt4(16682), Krt4(16682), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691)
rat ... Krt1(300250), Krt1-18(706059), Krt1-18(706059), Krt10(450225), Krt10(450225), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626)

Gene Information

bovine ... Krt1(100301161)
dog ... Krt1(444857)
human ... KRT1(3848), KRT1(3848), KRT1(3848), KRT5(3852), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856), KRT8(3856)
mouse ... KRT1(16678), KRT1(16678), KRT1(16678), Krt1(16678), Krt5(110308), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691), Krt8(16691)
rat ... Krt1(300250), Krt2-5(369017), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626), Krt2-8(25626)

Gene Information

bovine ... Krt1(100301161)
human ... KRT1(3848), KRT13(3858), KRT13(3858), KRT18(3875), KRT18(3875), KRT4(3851), KRT4(3851), KRT5(3852), KRT5(3852), KRT6A(3868), KRT6A(3868), KRT6B(3854), KRT6B(3854), KRT8(3856), KRT8(3856)
mouse ... Krt1(16678), Krt10(16661), Krt10(16661), Krt13(16663), Krt13(16663), Krt18(16668), Krt18(16668), Krt4(16682), Krt4(16682), Krt5(110308), Krt5(110308), Krt6a(16687), Krt6a(16687), Krt6b(16688), Krt6b(16688), Krt8(16691), Krt8(16691)
rat ... Krt1(300250), Krt1-18(706059), Krt1-18(706059), Krt10(450225), Krt10(450225), Krt2-5(369017), Krt2-5(369017), Krt2-8(25626), Krt2-8(25626)

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

purified from hybridoma cell culture

antibody form

purified immunoglobulin

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

FITC conjugate

species reactivity

human, chicken, snake, hamster, pig, goat, feline, bovine, carp, rat, rabbit, canine, lizard, sheep, mouse, guinea pig

species reactivity

bovine, mouse, frog, human, kangaroo rat, rat

species reactivity

human, chicken, snake, hamster, pig, goat, feline, bovine, carp, rat, rabbit, canine, lizard, sheep, mouse, guinea pig

species reactivity

bovine, mouse, frog, human, kangaroo rat, rat

Descripción general

Cytokeratin belongs to the member of intermediate filament (IF) protein family.
Cytokeratins, a group comprising at least 29 different proteins are characteristic of epithelial and trichocytic cells. Cytokeratin 1, 5, 6, and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin peptide 1 (68 kDa) is expressed together with cytokeratin 10 in the suprabasal cell layers or the differentiation compartment of the epidermis. Its expression increases with epidermal maturation and it is modified post-translationally in the terminally differentiated keratinocytes of the stratum corneum. Cytokeratin peptide 5 (58 kDa) is the primary type II keratin in stratified epithelia while cytokeratin type 8 (52 kDa) is a major type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a "hyperproliferation" cytokeratin expressed in tissues with natural or pathological high turnover.

Especificidad

The antibody recognizes an epitope located on the Type II cytokeratins 1, 5, 6, and 8. PCK-26 is a broad spectrum antibody which reacts specifically with a variety of normal, reactive, and neoplastic epithelial tissues. The antibody reacts with simple, cornifying, and non-cornifying squamous epithelia and pseudostratified epithelia.

Inmunógeno

cytokeratin from human epidermis.

Aplicación

Monoclonal antibodies to cytokeratins are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification. Monoclonal Anti-Cytokeratin, pan is a broadly reactive group-type antibody which recognizes an epitope present in most human epithelial tissues. It facilitates the typing of normal, metaplastic and neoplastic cells and it may aid in the discrimination of carcinomas and non-epithelial tumors such as sarcomas, lymphomas and neural tumors. It is also useful in detecting micro-metastases in lymph nodes and other tissues and for determining the origin of poorly differentiated tumors.
Monoclonal Anti-Cytokeratin, pan may be used for the localization of cytokeratins using various immunochemical assays such as immunoblotting, dot blotting, and immunohistochemstry (immunofluorescence and immunoenzymatic staining).
A minimum antibody titer of 1:300 was determined by indirect immunofluorescent staining of protease digested, formalin-fixed, paraffin-embedded sections of human or animal tissues.

Acciones bioquímicas o fisiológicas

Pan-cytokeratin along with the expression of CXCR4, may be a prognostic biomarker for non-small cell lung cancer (NSCLC).

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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