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C6286

Cathepsin B from bovine spleen

lyophilized powder, ≥10 units/mg protein

Sinónimos:

Cathepsin B1

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10 units
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179,00 €
25 units
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627,00 €
100 units
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1010,00 €

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Número CAS:
9047-22-7
UNSPSC Code:
12352204
NACRES:
NA.32
Número CE:
3.4.22.1 (BRENDA, IUBMB)
MDL number:
MFCD02662345
Specific activity:
≥10 units/mg protein
Biological source:
bovine spleen

179,00 €

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biological source

bovine spleen

Quality Segment

form

lyophilized powder

specific activity

≥10 units/mg protein

composition

Protein, ≥30% biuret

UniProt accession no.

storage temp.

−20°C

Gene Information

cow ... CTSB(281105)

General description

Cathepsin B is a lysosomal enzyme that comprises a light chain (Lys1–Arg49) and a heavy chain (Val50–Thr253). It belongs to cysteine family C1.

Application

Cathepsin B from bovine spleen has been used in cleavage assay before high-performance liquid chromatography-mass spectrometry (HPLC-MS) analysis. It has also been used in the enzyme inhibition assays with protease inhibitors RfIP1 and ruthenium metalloarenes.

Biochem/physiol Actions

Cathepsin B displays an endopeptidase and peptidyl dipeptidase activities. It may be associated with the pathophysiology of tumors. Cathepsin B is also regarded as a prominent protease in Leishmaniasis. It is overactivated in muscular dystrophy, pulmonary emphysema, and bone resorption.
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells.

Physical form

Lyophilized powder containing sodium phosphate, sodium chloride and ~6% EDTA as stabilizer.

Other Notes

One unit will hydrolyze 1 μmole of Z-lysine p-nitrophenyl ester per min at pH 5.0 at 25 °C.

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Cathepsin B from bovine spleen lyophilized powder, ≥10 units/mg protein

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description

lyophilized powder, ≥10 units/mg protein

description

lyophilized powder, ≥2.0 units/mg protein

description

Type X, lyophilized powder, ≥5 units/mg protein

description

lyophilized powder, ≥5 units/mg protein

Gene Information

cow ... CTSB(281105)

Gene Information

cow ... CTSD(282883)

Gene Information

cow ... CTSC(352958)

Gene Information

human ... CTSB(1508)

biological source

bovine spleen

biological source

bovine spleen

biological source

bovine spleen

biological source

-

specific activity

≥10 units/mg protein

specific activity

≥2.0 units/mg protein

specific activity

≥5 units/mg protein

specific activity

≥5 units/mg protein

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

form

lyophilized powder

UniProt accession no.

P07688

UniProt accession no.

P80209

UniProt accession no.

-

UniProt accession no.

P07858

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Clase de almacenamiento

11 - Combustible Solids

¿Qué está pasando?

WGK 3

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)

Not applicable

EPI (equipos de protección individual)

Eyeshields, Gloves, type N95 (US)

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